3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

Base Information

• Chemical Name: 3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione
• CAS No.: 110164-06-2
• Molecular Formula: C₁₉H₂₂N₄O₃S
• Molecular Weight: 386.475
• Mol file: 110164-06-2.mol

Synonyms:3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

Chemical Property of 3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

There total 3 articles about 3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

ethyl (4-methoxycarbonyl)thiophene-3-carbamate (118252-16-7) + 1-(2-aminoethyl)-4-(2-methoxyphenyl)piperazine (40255-48-9) → 3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione (110164-06-2)

Guidance literature:

With trimethylaluminum; In toluene; 0 --> 100 degC;

Reference yield:

1-(2-methoxyphenyl)piperazine hydrochloride (5464-78-8) + N-(3-carbomethoxythien-4-yl)-N'-(2-chloroethyl)urea (110164-47-1) → 3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione (110164-06-2)

Guidance literature:

With sodium hydroxide; sodium iodide; sodium hydrogencarbonate; In tetrahydrofuran; methanol;

Reference yield:

methyl 3-amino-4-thiophenecarboxylate hydrochloride (39978-14-8) → 3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione (110164-06-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / aq. NaOH / CH₂Cl₂ / 2 h / Ambient temperature

2: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

With sodium hydroxide; trimethylaluminum; In dichloromethane; toluene;

upstream raw materials:

ethyl (4-methoxycarbonyl)thiophene-3-carbamate

1-(2-aminoethyl)-4-(2-methoxyphenyl)piperazine

methyl 3-amino-4-thiophenecarboxylate hydrochloride

1-(2-methoxyphenyl)piperazine hydrochloride

Downstream raw materials:

ethyl 5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]pentanoate

1-<2-(Methoxycarbonyl)ethyl>-3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

3,4,5,7-tetrahydro-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione

9-amino-3,4,5,7,8,9-hexahydro-4-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<4,3,2-de>pyrido<1,2-c>pyrimidine-3,5-dione