Ethanone, 1-(2-amino-3-chloro-4-methoxyphenyl)-

Base Information

• Chemical Name: Ethanone, 1-(2-amino-3-chloro-4-methoxyphenyl)-
• CAS No.: 923289-36-5
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.637
• Hs Code.: 2922509090
• Mol file: 923289-36-5.mol

Synonyms:Ethanone, 1-(2-amino-3-chloro-4-methoxyphenyl)-;6-ACETYL-2-CHLORO-3-METHOXY ANILINE;1-(2-Amino-3-chloro-4-methoxyphenyl)ethanone;(2-Amino-3-chloro-4-methoxyphenyl)acetone;1-(2-Amino-3-chloro-4-methoxyphenyl)ethan-1-one, 6-Acetyl-2-chloro-3-methoxyaniline, 4-Acetyl-3-amino-2-chloroanisole;2-Amino-3-chloro-4-methoxyacetophenone;1-(2-aMino-3-chloro-4-Methoxyphenyl)ethan-1-one

Chemical Property of Ethanone, 1-(2-amino-3-chloro-4-methoxyphenyl)-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.568
• Boiling Point: 366.8ºC at 760 mmHg
• Flash Point: 175.6ºC
• PSA: 52.32000
• Density: 1.259 g/cm³
• LogP: 2.71460
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

1-(2-Amino-3-chloro-4-methoxyphenyl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(2-amino-3-chloro-4-methoxyphenyl)-

There total 2 articles about Ethanone, 1-(2-amino-3-chloro-4-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

acetonitrile (75-05-8,26809-02-9) → 1-(2-amino-3-chloro-4-methoxy-phenyl)ethanone (923289-36-5)

Guidance literature:

2-chloro-3-methoxyphenylamine; With boron trichloride; In dichloromethane; xylene; at 5 - 10 ℃; for 0.5h;

acetonitrile; In dichloromethane; xylene; at 5 ℃; for 0.5h;

With aluminum (III) chloride; sodium hydroxide; water; more than 3 stages; Product distribution / selectivity;

Reference yield:

2-chloro-3-methoxyphenylamine (113206-03-4) + acetonitrile (75-05-8,26809-02-9) → 1-(2-amino-3-chloro-4-methoxy-phenyl)ethanone (923289-36-5)

Guidance literature:

2-chloro-3-methoxyphenylamine; With boron trichloride; In 5,5-dimethyl-1,3-cyclohexadiene; at 0 ℃;

acetonitrile; With aluminum (III) chloride; In 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; at 0 - 70 ℃;

DOI:10.1016/j.bmcl.2008.07.088

Reference yield: 69.0%

oxalyl dichloride (79-37-8) + 1-(2-amino-3-chloro-4-methoxy-phenyl)ethanone (923289-36-5) + lithium 2-(trifluoromethyl)thiazole-4-carboxylate (1180496-14-3) → N-(6-acetyl-2-chloro-3-methoxyphenyl)-2-(trifluoromethyl)thiazole-4-carboxamide (1180496-15-4)

Guidance literature:

In 1,4-dioxane; methanol; diethyl ether; dichloromethane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;

upstream raw materials:

acetonitrile

2-chloro-3-methoxyphenylamine

Downstream raw materials:

N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-isopropylthiazole-2-carboxamide

N-(6-acetyl-2-chloro-3-methoxyphenyl)-5-isopropylisoxazole-3-carboxamide

N-(6-acetyl-2-chloro-3-methoxyphenyl)-2-isopropylthiazole-4-carboxamide

N-(6-acetyl-2-chloro-3-methoxyphenyl)-4-trifluoromethylthiazole-2-carboxamide