(S)-7-allyl-tert-butoxycarbonylamino-8-(tert-butyldiphenylsilanyloxy)octanoic acid methyl ester

Base Information

Chemical Name:(S)-7-allyl-tert-butoxycarbonylamino-8-(tert-butyldiphenylsilanyloxy)octanoic acid methyl ester
CAS No.:1057664-60-4
Molecular Formula:C₃₃H₄₉NO₅Si
Molecular Weight:567.841
Hs Code.:

Synonyms:(S)-7-allyl-tert-butoxycarbonylamino-8-(tert-butyldiphenylsilanyloxy)octanoic acid methyl ester

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Chemical Property of (S)-7-allyl-tert-butoxycarbonylamino-8-(tert-butyldiphenylsilanyloxy)octanoic acid methyl ester

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Technology Process of (S)-7-allyl-tert-butoxycarbonylamino-8-(tert-butyldiphenylsilanyloxy)octanoic acid methyl ester

There total 5 articles about (S)-7-allyl-tert-butoxycarbonylamino-8-(tert-butyldiphenylsilanyloxy)octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 556-56-9
allyl iodid

: 1057664-58-0
7-(S)-tert-butoxycarbonylamino-8-(tert-butyldiphenylsilanyloxy)octanoic acid methyl ester

: 1057664-60-4
(S)-7-allyl-tert-butoxycarbonylamino-8-(tert-butyldiphenylsilanyloxy)octanoic acid methyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 1h; Inert atmosphere; Cooling with ice;
DOI:10.1021/jm101092u

Reference yield:

: 1057664-56-8
8-(tert-butyldiphenylsilanyloxy)-7-(R)-hydroxyoctanoic acid methyl ester

: 1057664-60-4
(S)-7-allyl-tert-butoxycarbonylamino-8-(tert-butyldiphenylsilanyloxy)octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate / toluene / 24 h / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h

3.1: dichloromethane / 24 h

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

4.2: 0.17 h / 20 °C

With diphenyl phosphoryl azide; hydrogen; sodium hydride; triphenylphosphine; diethylazodicarboxylate; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1057664-57-9
(S)-7-azido-8-(tert-butyldiphenylsilanyloxy)octanoic acid methyl ester

: 1057664-60-4
(S)-7-allyl-tert-butoxycarbonylamino-8-(tert-butyldiphenylsilanyloxy)octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h

2.1: dichloromethane / 24 h

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

3.2: 0.17 h / 20 °C

With hydrogen; sodium hydride; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;