(R)-5-Hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

Base Information

Chemical Name:(R)-5-Hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester
CAS No.:215317-20-7
Molecular Formula:C₂₆H₃₃NO₆
Molecular Weight:455.551
Hs Code.:

Synonyms:(R)-5-Hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

Suppliers and Price of (R)-5-Hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-Hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

Chemical Property:

Purity/Quality:: 98% HPLC ^*data from raw suppliers

Safty Information:

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Technology Process of (R)-5-Hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

There total 6 articles about (R)-5-Hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.4%

: 215317-19-4
(R)-5-(Biphenyl-4-yloxymethoxy)-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

: 215317-20-7
(R)-5-Hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

Guidance literature:: With sulfuric acid; In tetrahydrofuran; methanol; at 23 ℃; for 22h;
DOI:10.1021/jo9809229

Reference yield:

: 215317-11-6
(R)-3-(2-phenylethyl)-3-[(4-phenylphenoxy)methoxy]hexanol

: 215317-20-7
(R)-5-Hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 98.6 percent / KBr, NaHCO₃, 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy, NaOCl / H₂O / 1 h / 1 - 5 °C

2: 89.7 percent / NaHMDS / tetrahydrofuran / -90 - -71 °C

3: 99.2 percent / PCC, NaOAc, Florisil / CH₂Cl₂ / 20 h / Ambient temperature

4: 84.4 percent / H₂SO₄ / methanol; tetrahydrofuran / 22 h / 23 °C

With sodium hypochlorite; florisil; TEMPOL; sulfuric acid; sodium acetate; sodium hexamethyldisilazane; sodium hydrogencarbonate; pyridinium chlorochromate; potassium bromide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo9809229

Reference yield:

: 215317-14-9
(R)-3-(2-phenylethyl)-3-[(4-phenylphenoxy)methoxy]hexanal

: 215317-20-7
(R)-5-Hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-3-oxo-5-phenethyl-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89.7 percent / NaHMDS / tetrahydrofuran / -90 - -71 °C

2: 99.2 percent / PCC, NaOAc, Florisil / CH₂Cl₂ / 20 h / Ambient temperature

3: 84.4 percent / H₂SO₄ / methanol; tetrahydrofuran / 22 h / 23 °C

With florisil; sulfuric acid; sodium acetate; sodium hexamethyldisilazane; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo9809229