(3-DIMETHYLAMINO)-1''-PROPIONAPTHONE HYDROCHLORIDE

Base Information

• Chemical Name: (3-DIMETHYLAMINO)-1''-PROPIONAPTHONE HYDROCHLORIDE
• CAS No.: 5409-58-5
• Molecular Formula: C15H17 N O . Cl H
• Molecular Weight: 263.767
• Hs Code.: 2922399090
• Mol file: 5409-58-5.mol

Synonyms:1-Propanone,3-(dimethylamino)-1-(1-naphthalenyl)-, hydrochloride (9CI); 1'-Propionaphthone,3-(dimethylamino)-, hydrochloride (7CI,8CI);3-Dimethylamino-1-(naphthalen-1-yl)propan-1-one hydrochloride

Chemical Property of (3-DIMETHYLAMINO)-1''-PROPIONAPTHONE HYDROCHLORIDE

Chemical Property:

• Melting Point: 165℃
• Boiling Point: 368.7°Cat760mmHg
• Flash Point: 139.4°C
• PSA: 20.31000
• Density: 1.072g/cm³
• LogP: 3.77620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Ethanol, Methanol, Water

Purity/Quality:

99.5%+ ^*data from raw suppliers

3-(Dimethylamino)-1-(1-naphthalenyl)-1-propanoneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(Dimethylamino)-1-(1-naphthalenyl)-1-propanone Hydrochloride is a reactant used in the preparation of choline acetyltransferase (ChA) inhibitors.

Technology Process of (3-DIMETHYLAMINO)-1''-PROPIONAPTHONE HYDROCHLORIDE

There total 2 articles about (3-DIMETHYLAMINO)-1''-PROPIONAPTHONE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1'-naphthacetophenone (941-98-0) + N,N-dimethyl(methylene)ammonium chloride (30354-18-8) → 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one hydrochloride (5409-58-5)

Guidance literature:

In acetonitrile; at 110 ℃; Inert atmosphere;

DOI:10.1039/c5md00131e

Reference yield:

1'-naphthacetophenone (941-98-0) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + N,N-dimethylammonium chloride (506-59-2) → 3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one hydrochloride (5409-58-5)

Guidance literature:

With hydrogenchloride; In ethanol; water; for 10h; Heating / reflux;

Reference yield: 98.2%

3-(dimethylamino)-1-(naphthalen-1-yl)propan-1-one hydrochloride (5409-58-5) → 3-(dimethylamino)-1-(1-naphthalenyl)-1-propanone (10320-49-7)

Guidance literature:

With sodium hydroxide; In water; toluene; at 20 ℃; for 0.416667 - 0.666667h;

upstream raw materials:

1'-naphthacetophenone

formaldehyd

N,N-dimethylammonium chloride

N,N-dimethyl(methylene)ammonium chloride

Downstream raw materials:

3-naphthalen-1-yl-1-phenyl-4,5-dihydro-1H-pyrazole

1-(naphthalen-1-yl)-3-tosylpropan-1-one

1-(naphthalen-1-yl)-3-(phenylsulfonyl)propan-1-one

3-(dimethylamino)-1-(1-naphthalenyl)-1-propanone