Technology Process of 5,5-difluoro-3,7-dimethyl-10-phenyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine
There total 4 articles about 5,5-difluoro-3,7-dimethyl-10-phenyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2',1'-f][1,3,2]diazaborinine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-methyl-1H-pyrrole; benzoyl chloride;
In
1,2-dichloro-ethane;
at 20 ℃;
for 12.5h;
Inert atmosphere;
With
triethylamine;
In
1,2-dichloro-ethane;
at 0 ℃;
for 0.333333h;
Inert atmosphere;
boron trifluoride diethyl etherate;
In
1,2-dichloro-ethane;
for 1h;
Inert atmosphere;
Reflux;
- Guidance literature:
-
In
dichloromethane;
(N2, shielded from light) isoindole-compound and aldehyde-compound were added to CH2Cl2, stirred under N2 for 10 min, BF3*O(C2H5)2 was added, stirred for 2.5 h, DDQ was added, stirred for 18 h; the soln. was washed with 10% aq. Na2SO4 and brine, dried (MgSO4), filtered, concd. in vac., column chromy. on silica gel, CH2Cl2, CH2Cl2-THF (20:1), washed with 5% aq. HCl and water, dried (MgSO4), filtered, rotary evapd., crystd. from CH2Cl2-O(C2H5)2;
DOI:10.1021/ja108493b
- Guidance literature:
-
2-methyl-1H-pyrrole; benzaldehyde;
With
trifluoroacetic acid;
In
dichloromethane;
for 12h;
Inert atmosphere;
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane;
at 20 ℃;
for 2h;
Inert atmosphere;
boron trifluoride diethyl etherate;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1002/anie.202012764
