1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-2-hydroxy-3-propylphenyl>ethanone hydrochloride

Base Information

• Chemical Name: 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-2-hydroxy-3-propylphenyl>ethanone hydrochloride
• CAS No.: 117023-93-5
• Molecular Formula: C₃₂H₃₇F₂NO₅*ClH
• Molecular Weight: 590.107

Synonyms:1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-2-hydroxy-3-propylphenyl>ethanone hydrochloride

Chemical Property of 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-2-hydroxy-3-propylphenyl>ethanone hydrochloride

Chemical Property:

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Technology Process of 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-2-hydroxy-3-propylphenyl>ethanone hydrochloride

There total 4 articles about 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-2-hydroxy-3-propylphenyl>ethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

3-(2-n-Propyl-3-hydroxy-4-acetylphenoxy)-1,2-epoxypropane (57161-85-0) + 1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol (60284-98-2) → 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-2-hydroxy-3-propylphenyl>ethanone hydrochloride (117023-93-5)

Guidance literature:

In ethanol; for 48h; Ambient temperature;

DOI:10.1021/jm00121a022

Reference yield:

N-benzyl isonipecotic acid ethyl ester (24228-40-8) → 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-2-hydroxy-3-propylphenyl>ethanone hydrochloride (117023-93-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 41 percent / ethanol / 48 h / Ambient temperature

With hydrogen; magnesium; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00121a022

Reference yield:

α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol (111627-25-9) → 1-<4-<3-<4--1-piperidinyl>-2-hydroxypropoxy>-2-hydroxy-3-propylphenyl>ethanone hydrochloride (117023-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

2: 41 percent / ethanol / 48 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00121a022

upstream raw materials:

3-(2-n-Propyl-3-hydroxy-4-acetylphenoxy)-1,2-epoxypropane

1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

N-benzyl isonipecotic acid ethyl ester

α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol

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