Ethyl 1-Boc-4-ethyl-4-piperidine carboxylate

Base Information

• Chemical Name: Ethyl 1-Boc-4-ethyl-4-piperidine carboxylate
• CAS No.: 188792-70-3
• Molecular Formula: C15H27NO4
• Molecular Weight: 285.3792
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID70693903
• Wikidata: Q82622888
• Mol file: 188792-70-3.mol

Synonyms:188792-70-3;Ethyl 1-Boc-4-ethyl-4-piperidine carboxylate;1-tert-butyl 4-ethyl 4-ethylpiperidine-1,4-dicarboxylate;1-O-tert-butyl 4-O-ethyl 4-ethylpiperidine-1,4-dicarboxylate;MFCD10565657;Ethyl1-Boc-4-ethyl-4-piperidinecarboxylate;SCHEMBL963907;DTXSID70693903;AKOS015903998;SB43213;1,4-Piperidinedicarboxylic acid, 4-ethyl-, 1-(1,1-dimethylethyl) 4-ethyl ester;AC-22839;AS-31509;SY002355;CS-0152566;ethyl 1-boc-4-ethylpiperidine-4-carboxylate;Ethyl N-Boc-4-ethylpiperidine-4-carboxylate;FT-0690062;A23128;1-tert-butoxycarbonyl-4-ethylisonipecotic acid ethyl ester;tert-butyl 4-ethyl-4-ethoxycarbonylpiperidine-1-carboxylate;1-(tert-butyl) 4-ethyl 4-ethylpiperidine-1,4-dicarboxylate

Chemical Property of Ethyl 1-Boc-4-ethyl-4-piperidine carboxylate

Chemical Property:

• Vapor Pressure: 5.99E-05mmHg at 25°C
• Refractive Index: 1.467
• Boiling Point: 345.9 °C at 760 mmHg
• PKA: -2.20±0.40(Predicted)
• Flash Point: 163 °C
• PSA: 55.84000
• Density: 1.038 g/cm³
• LogP: 2.91470
• Storage Temp.: 2-8°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 285.19400834
• Heavy Atom Count: 20
• Complexity: 351

Purity/Quality:

97% ^*data from raw suppliers

Ethyl1-boc-4-ethyl-4-piperidinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCC1(CCN(CC1)C(=O)OC(C)(C)C)C(=O)OCC

Technology Process of Ethyl 1-Boc-4-ethyl-4-piperidine carboxylate

There total 6 articles about Ethyl 1-Boc-4-ethyl-4-piperidine carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl iodide (75-03-6) + 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate (142851-03-4) + lithium diisopropyl amide (4111-54-0) → ethyl 1-boc-4-ethyl-4-piperidine carboxylate (188792-70-3)

Guidance literature:

In tetrahydrofuran; water; argon;

Reference yield: 82.9%

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate (124443-68-1) + ethyl iodide (75-03-6) → ethyl 1-boc-4-ethyl-4-piperidine carboxylate (188792-70-3)

Guidance literature:

1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

ethyl iodide; In tetrahydrofuran; at -78 - 20 ℃; for 1.5h; Inert atmosphere;

Reference yield: 82.0%

ethyl iodide (75-03-6) + 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate (142851-03-4) → ethyl 1-boc-4-ethyl-4-piperidine carboxylate (188792-70-3)

Guidance literature:

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at -10 ℃;

ethyl iodide; In tetrahydrofuran; at 20 ℃;

With ammonium chloride; In tetrahydrofuran;

upstream raw materials:

ethyl iodide

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

lithium diisopropyl amide

4-carbethoxypiperidine

Downstream raw materials:

1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid

1-boc-4-ethyl-4-formylpiperidine