Technology Process of 1,2-difluoro-3-(4-iodophenoxy)benzene
There total 4 articles about 1,2-difluoro-3-(4-iodophenoxy)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(2,3-difluoro-phenoxy)-phenylamine;
With
hydrogenchloride; sodium nitrite;
In
water;
at 0 ℃;
for 0.5h;
With
urea;
In
water;
at 0 ℃;
for 0.333333h;
With
sodium iodide;
In
water;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.25 h / 0 - 20 °C / Inert atmosphere
1.2: 12 h / 100 °C
2.1: hydrazine hydrate / methanol / 12 h / 25 °C / Inert atmosphere
3.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C
3.2: 0.33 h / 0 °C
3.3: 1 h / 20 °C
With
hydrogenchloride; sodium hydride; hydrazine hydrate; sodium nitrite;
In
methanol; water; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dihydrogen peroxide / dichloromethane / 2 h / 25 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.25 h / 0 - 20 °C / Inert atmosphere
2.2: 12 h / 100 °C
3.1: hydrazine hydrate / methanol / 12 h / 25 °C / Inert atmosphere
4.1: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 °C
4.2: 0.33 h / 0 °C
4.3: 1 h / 20 °C
With
hydrogenchloride; dihydrogen peroxide; sodium hydride; hydrazine hydrate; sodium nitrite;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
