4‐(6‐amino‐3,5‐dicyano‐4‐(4‐methoxyphenyl)‐2‐oxopyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide

Base Information

• Chemical Name: 4‐(6‐amino‐3,5‐dicyano‐4‐(4‐methoxyphenyl)‐2‐oxopyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide
• CAS No.: 1627962-89-3
• Molecular Formula: C₂₄H₁₈N₆O₅S
• Molecular Weight: 502.51

Synonyms:4‐(6‐amino‐3,5‐dicyano‐4‐(4‐methoxyphenyl)‐2‐oxopyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide

Chemical Property of 4‐(6‐amino‐3,5‐dicyano‐4‐(4‐methoxyphenyl)‐2‐oxopyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide

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Technology Process of 4‐(6‐amino‐3,5‐dicyano‐4‐(4‐methoxyphenyl)‐2‐oxopyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide

There total 5 articles about 4‐(6‐amino‐3,5‐dicyano‐4‐(4‐methoxyphenyl)‐2‐oxopyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(4-methoxyphenylmethylene)malononitrile (2826-26-8) + 2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acetamide (901373-59-9) → 4‐(6‐amino‐3,5‐dicyano‐4‐(4‐methoxyphenyl)‐2‐oxopyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide (1627962-89-3)

Guidance literature:

With piperidine; In pyridine; Reflux;

DOI:10.1002/jhet.3737

Reference yield: 56.0%

2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acetamide (901373-59-9) + 4-methoxy-benzaldehyde (123-11-5) + malononitrile (109-77-3) → 4‐(6‐amino‐3,5‐dicyano‐4‐(4‐methoxyphenyl)‐2‐oxopyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide (1627962-89-3)

Guidance literature:

With piperidine; In 1,4-dioxane; for 3h; Reflux;

DOI:10.3987/COM-14-12954

Reference yield:

sulfamethoxazole (723-46-6) → 4‐(6‐amino‐3,5‐dicyano‐4‐(4‐methoxyphenyl)‐2‐oxopyridin‐1(2H)‐yl)‐N‐(5‐methylisoxazol‐3‐yl)benzenesulfonamide (1627962-89-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dioxane / 3 h / Reflux

2: piperidine / 1,4-dioxane / 3 h / Reflux

With piperidine; In 1,4-dioxane;

DOI:10.3987/COM-14-12954

upstream raw materials:

2-cyano-N-(4-{[(5-methylisoxazol-3-yl)amino]sulfonyl}phenyl)acetamide

4-methoxy-benzaldehyde

malononitrile

2-(4-methoxyphenylmethylene)malononitrile

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