(2S,4S)-tert-butyl 4-(benzyloxy)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(2S,4S)-tert-butyl 4-(benzyloxy)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate
CAS No.:176306-34-6
Molecular Formula:C₁₉H₂₈N₂O₅
Molecular Weight:364.442
Hs Code.:

Synonyms:(2S,4S)-tert-butyl 4-(benzyloxy)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate

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Chemical Property of (2S,4S)-tert-butyl 4-(benzyloxy)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate

Chemical Property:

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Technology Process of (2S,4S)-tert-butyl 4-(benzyloxy)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate

There total 4 articles about (2S,4S)-tert-butyl 4-(benzyloxy)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 40350-83-2,54631-81-1,54631-82-2
(2S,4S)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 176306-34-6
(2S,4S)-tert-butyl 4-(benzyloxy)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: [S-(R*,R*)]-4-Phenylmethoxy-1,2-pyrrolidinedicarboxylic acid,1,1-dimethylethyl ester

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 132705-51-2
bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate

: 176306-34-6
(2S,4S)-tert-butyl 4-(benzyloxy)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: With dmap; In dichloromethane;

Reference yield:

: 100-39-0
benzyl bromide

: 176306-34-6
(2S,4S)-tert-butyl 4-(benzyloxy)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 16 h / 0 - 20 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 20 °C

With sodium hydride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; mineral oil;