4,4'-((4-methoxy-1,3-phenylene)bis(methylene))bis(methoxybenzene)

Base Information

• Chemical Name: 4,4'-((4-methoxy-1,3-phenylene)bis(methylene))bis(methoxybenzene)
• CAS No.: 72046-76-5
• Molecular Formula: C₂₃H₂₄O₃
• Molecular Weight: 348.442
• Mol file: 72046-76-5.mol

Synonyms:4,4'-((4-methoxy-1,3-phenylene)bis(methylene))bis(methoxybenzene)

Chemical Property of 4,4'-((4-methoxy-1,3-phenylene)bis(methylene))bis(methoxybenzene)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4'-((4-methoxy-1,3-phenylene)bis(methylene))bis(methoxybenzene)

There total 8 articles about 4,4'-((4-methoxy-1,3-phenylene)bis(methylene))bis(methoxybenzene) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

p-methoxybenzyl benzoate (24318-41-0) + methoxybenzene (100-66-3) → 4,4'-((4-methoxy-1,3-phenylene)bis(methylene))bis(methoxybenzene) (72046-76-5) + 4,4'-dianisylmethane (726-18-1) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

With proton-exchanged montmorillonite; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tet.2014.01.064

Reference yield: 83.0%

1,3-dichloro-4-methoxybenzene (553-82-2) + 4-Methylbenzyl chloride (104-82-5) → 4,4'-((4-methoxy-1,3-phenylene)bis(methylene))bis(methoxybenzene) (72046-76-5)

Guidance literature:

With Ni(IBiox-6)[P(OEt)₃]Br₂; magnesium; In tetrahydrofuran; at 50 ℃; for 8h; Schlenk technique; Glovebox;

DOI:10.1021/acs.organomet.0c00515

Reference yield: 80.0%

1-bromo-4-methoxy-benzene (104-92-7) + 2,4-bis(bromomethyl)-1-methoxybenzene (83020-58-0) → 4,4'-((4-methoxy-1,3-phenylene)bis(methylene))bis(methoxybenzene) (72046-76-5)

Guidance literature:

1-bromo-4-methoxy-benzene; With n-butyllithium; In diethyl ether; hexane; at 20 ℃; for 1h; Inert atmosphere;

With zinc(II) chloride; In diethyl ether; hexane; at 20 ℃; for 3h; Inert atmosphere;

2,4-bis(bromomethyl)-1-methoxybenzene; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201411403

upstream raw materials:

9-(4-methoxy-benzyl)-9-bora-bicyclo[3.3.1]nonane

2,4-dibromoanisole

4-methoxybenzylmagnesium chloride

4-Methoxybenzyl alcohol