methyl 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoate

Base Information

Chemical Name:methyl 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoate
CAS No.:1396723-05-9
Molecular Formula:C₂₁H₁₉ClN₂O₂
Molecular Weight:366.847
Hs Code.:

Synonyms:methyl 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoate

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Chemical Property of methyl 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoate

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Technology Process of methyl 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoate

There total 5 articles about methyl 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1196-70-9
indole-6-carboxaldehyde

: 1396723-01-5
methyl 4-(azetidin-3-ylidenemethyl)-3-chlorobenzoate hydrochloride

: 1396723-05-9
methyl 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoate

Guidance literature:: methyl 4-(azetidin-3-ylidenemethyl)-3-chlorobenzoate hydrochloride; With triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 0.333333h;

indole-6-carboxaldehyde; With sodium tris(acetoxy)borohydride; In tetrahydrofuran; dichloromethane; at 50 ℃;

Reference yield:

: 56525-63-4
methyl 3-chloro-4-methyl-benzoate

: 1396723-05-9
methyl 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 6 h / Reflux

2.1: toluene / 6 h / 70 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oill / 0.25 h / 0 °C

3.2: 65 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C

5.1: triethylamine / dichloromethane; tetrahydrofuran / 0.33 h / 20 °C

5.2: 50 °C

With hydrogenchloride; N-Bromosuccinimide; sodium hydride; triethylamine; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; paraffin oill; N,N-dimethyl-formamide; toluene;

Reference yield:

: 74733-30-5
methyl 4-Bromomethyl-3-chlorobenzoate

: 1396723-05-9
methyl 4-((1-((1H-indol-6-yl)methyl)azetidin-3-ylidene)methyl)-3-chlorobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 6 h / 70 °C

2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oill / 0.25 h / 0 °C

2.2: 65 °C

3.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C

4.1: triethylamine / dichloromethane; tetrahydrofuran / 0.33 h / 20 °C

4.2: 50 °C

With hydrogenchloride; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; paraffin oill; N,N-dimethyl-formamide; toluene;