ethyl 3-(2-fluorophenyl)-7-benzoylpyrrolo[1,2-c]pyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl 3-(2-fluorophenyl)-7-benzoylpyrrolo[1,2-c]pyrimidine-5-carboxylate
CAS No.:1566622-45-4
Molecular Formula:C₂₃H₁₇FN₂O₃
Molecular Weight:388.398
Hs Code.:

Synonyms:ethyl 3-(2-fluorophenyl)-7-benzoylpyrrolo[1,2-c]pyrimidine-5-carboxylate

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Chemical Property of ethyl 3-(2-fluorophenyl)-7-benzoylpyrrolo[1,2-c]pyrimidine-5-carboxylate

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Technology Process of ethyl 3-(2-fluorophenyl)-7-benzoylpyrrolo[1,2-c]pyrimidine-5-carboxylate

There total 2 articles about ethyl 3-(2-fluorophenyl)-7-benzoylpyrrolo[1,2-c]pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1235649-95-2
4-(2-fluorophenyl)pyrimidine

: 70-11-1
α-bromoacetophenone

: 623-47-2
propynoic acid ethyl ester

: 1566622-45-4
ethyl 3-(2-fluorophenyl)-7-benzoylpyrrolo[1,2-c]pyrimidine-5-carboxylate

Guidance literature:: With ethyloxirane; at 120 ℃; for 0.5h; Reagent/catalyst; Temperature; Sealed tube; Microwave irradiation; Green chemistry;
DOI:10.2174/13862073113169990050

Reference yield:

: 445-27-2
2'-Fluoroacetophenone

: 1566622-45-4
ethyl 3-(2-fluorophenyl)-7-benzoylpyrrolo[1,2-c]pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid

2: ethyloxirane / 0.5 h / 120 °C / Sealed tube; Microwave irradiation; Green chemistry

With ethyloxirane; toluene-4-sulfonic acid;
DOI:10.2174/13862073113169990050