diethyl 2-(1R)-(3-(4-bromophenyl)-1-(4-methoxyphenyl)-3-oxopropyl)malonate

Base Information

Chemical Name:diethyl 2-(1R)-(3-(4-bromophenyl)-1-(4-methoxyphenyl)-3-oxopropyl)malonate
CAS No.:1628735-86-3
Molecular Formula:C₂₃H₂₅BrO₆
Molecular Weight:477.352
Hs Code.:

Synonyms:diethyl 2-(1R)-(3-(4-bromophenyl)-1-(4-methoxyphenyl)-3-oxopropyl)malonate

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Chemical Property of diethyl 2-(1R)-(3-(4-bromophenyl)-1-(4-methoxyphenyl)-3-oxopropyl)malonate

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Technology Process of diethyl 2-(1R)-(3-(4-bromophenyl)-1-(4-methoxyphenyl)-3-oxopropyl)malonate

There total 3 articles about diethyl 2-(1R)-(3-(4-bromophenyl)-1-(4-methoxyphenyl)-3-oxopropyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 51863-81-1
3-(4-methoxyphenyl)-1-(4-bromophenyl)-2-propen-1-one

: 105-53-3
diethyl malonate

: 1628735-86-3
diethyl 2-(1R)-(3-(4-bromophenyl)-1-(4-methoxyphenyl)-3-oxopropyl)malonate

Guidance literature:: With C₉₃H₉₉N₆O₃⁽³⁺⁾*3Br^(1-); potassium carbonate; In water; toluene; at 20 ℃; for 1h; Reagent/catalyst; enantioselective reaction; Sonication;
DOI:10.1039/c4nj02395a

Reference yield: 91.0%

: 126443-12-7
4'-bromo-4-methoxy-trans-chalcone

: 105-53-3
diethyl malonate

: 1628735-86-3
diethyl 2-(1R)-(3-(4-bromophenyl)-1-(4-methoxyphenyl)-3-oxopropyl)malonate

Guidance literature:: With C₉₀H₉₆N₉O₃⁽³⁺⁾*3Br^(1-); potassium tert-butylate; In dichloromethane; for 4h; Reagent/catalyst; enantioselective reaction; Sonication;
DOI:10.1055/s-0033-1339124

Reference yield:

: 99-90-1
para-bromoacetophenone

: 123-11-5
4-methoxy-benzaldehyde

: 1628735-86-3
diethyl 2-(1R)-(3-(4-bromophenyl)-1-(4-methoxyphenyl)-3-oxopropyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol / 0.08 h

2: C₅₆H₆₂N₆O₂⁽²⁺⁾*2Br^(1-); sodium hydroxide / toluene; water / 2 h / 0 °C

With C₅₆H₆₂N₆O₂⁽²⁺⁾*2Br^(1-); sodium hydroxide; In ethanol; water; toluene; 2: |Michael Addition;
DOI:10.1016/j.tetlet.2015.07.074