N-[(4-Hydroxybenzoyl)acetyl]glycine

Base Information

Chemical Name:N-[(4-Hydroxybenzoyl)acetyl]glycine
CAS No.:3850-43-9
Molecular Formula:C₁₁H₁₃NO₄
Molecular Weight:223.229
Hs Code.:
DSSTox Substance ID:DTXSID701268844

Synonyms:3850-43-9;N-[(4-Hydroxybenzoyl)acetyl]glycine;Phloretylacetylglycine;2-[3-(4-hydroxyphenyl)propanoylamino]acetic acid;4-hydroxyphenylpropionylglycine;SCHEMBL1221588;DTXSID701268844;N-[3-(4-Hydroxyphenyl)-1-oxopropyl]glycine;2-[3-(4-hydroxyphenyl)propanamido]acetic acid;[3-(4-hydroxy-phenyl)propionylamino]-acetic acid;EN300-26358923;([3-(4-Hydroxyphenyl)propanoyl]amino)acetic acid #;[3-(4-hydroxy-phenyl) propionylamino]-acetic acid;Z2182042921

Suppliers and Price of N-[(4-Hydroxybenzoyl)acetyl]glycine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(4-Hydroxybenzoyl)acetyl]glycine

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:223.08445790
Heavy Atom Count:16
Complexity:246

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1CCC(=O)NCC(=O)O)O

Technology Process of N-[(4-Hydroxybenzoyl)acetyl]glycine

There total 9 articles about N-[(4-Hydroxybenzoyl)acetyl]glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 160538-48-7
[3-(4-Hydroxy-phenyl)-propionylamino]-acetic acid benzyl ester

: 3850-43-9
N-[3-(4-hydroxy-phenyl)-propionyl]-glycine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 2h;
DOI:10.1016/S0040-4039(00)74434-0

Reference yield:

: 2-[3-(4-hydroxyphenyl)propionylamino]acetic acid ethyl ester

: 3850-43-9
N-[3-(4-hydroxy-phenyl)-propionyl]-glycine

Guidance literature:: With sodium hydroxide; In water;

Reference yield:

: 501-97-3
4-hydroxyphenylpropionic acid

: 3850-43-9
N-[3-(4-hydroxy-phenyl)-propionyl]-glycine

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / N,N-dicyclohexyl carbodiimide, 1-hydroxy benzotriazole / dimethylformamide / 12 h / Ambient temperature

2: 92 percent / hydrogen / Pd-C / ethyl acetate / 2 h

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74434-0