[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-carbamic acid ethyl ester; compound with oxalic acid

Base Information

Chemical Name:[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-carbamic acid ethyl ester; compound with oxalic acid
CAS No.:117023-83-3
Molecular Formula:C₂H₂O₄*C₃₀H₃₄F₂N₂O₄
Molecular Weight:614.643
Hs Code.:

Synonyms:[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-carbamic acid ethyl ester; compound with oxalic acid

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Chemical Property of [4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-carbamic acid ethyl ester; compound with oxalic acid

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Technology Process of [4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-carbamic acid ethyl ester; compound with oxalic acid

There total 5 articles about [4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-carbamic acid ethyl ester; compound with oxalic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 144-62-7,97993-78-7
oxalic acid

: 60284-98-2
1,1-bis(4-fluorophenyl)-1-(4-piperidinyl)methanol

: 111627-61-3
N-[4-(3-Chloropropoxy)phenyl]carbamic acid ethyl ester

: 117023-83-3
[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-carbamic acid ethyl ester; compound with oxalic acid

Guidance literature:: With sodium carbonate; potassium iodide; 1) DMF, reflux;
DOI:10.1021/jm00121a022

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 117023-83-3
[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-carbamic acid ethyl ester; compound with oxalic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 50 percent / 1) Na₂CO₃, KI / 1) DMF, reflux

With hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00121a022

Reference yield:

: 111627-25-9
α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol

: 117023-83-3
[4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-piperidin-1-yl}-propoxy)-phenyl]-carbamic acid ethyl ester; compound with oxalic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

2: 50 percent / 1) Na₂CO₃, KI / 1) DMF, reflux

With hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00121a022