Propargyl-PEG7-alcohol

Base Information

• Chemical Name: Propargyl-PEG7-alcohol
• CAS No.: 944560-99-0
• Molecular Formula: C₁₅H₂₈O₇
• Molecular Weight: 320.383
• Mol file: 944560-99-0.mol

Synonyms:(2-(2-(2-(2-(2-(2-hydroxyethoxy)-ethoxy)-ethoxy)-ethoxy)-ethoxy)-ethyl) propargyl ether

Chemical Property of Propargyl-PEG7-alcohol

Chemical Property:

• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

HC≡C-CH2-PEG6-OH min.97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Propargyl-PEG7-alcohol is a propargyl linker that can react with azide compounds or biomolecules via copper catalyzed Click Chemistry.

Technology Process of Propargyl-PEG7-alcohol

There total 1 articles about Propargyl-PEG7-alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

pentaethylene glycol (2615-15-8) + propargyl bromide (106-96-7) → (2-(2-(2-(2-(2-(2-hydroxyethoxy)-ethoxy)-ethoxy)-ethoxy)-ethoxy)-ethyl) propargyl ether (944560-99-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; Reflux;

DOI:10.3390/molecules181113992

Reference yield: 90.0%

(2-(2-(2-(2-(2-(2-hydroxyethoxy)-ethoxy)-ethoxy)-ethoxy)-ethoxy)-ethyl) propargyl ether (944560-99-0) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-(3,6,9,12,15,18-hexaoxahenicos-20-ynyloxy)benzaldehyde

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃;

DOI:10.1021/acs.jmedchem.7b00191

Reference yield: 71.0%

(2-(2-(2-(2-(2-(2-hydroxyethoxy)-ethoxy)-ethoxy)-ethoxy)-ethoxy)-ethyl) propargyl ether (944560-99-0) + 4-Nitrophenyl chloroformate (7693-46-1) → C22H31NO11 (1422540-82-6)

Guidance literature:

With pyridine; In acetonitrile; at 0 - 20 ℃;

DOI:10.1039/c2ob26968f

upstream raw materials:

pentaethylene glycol

propargyl bromide

Downstream raw materials:

1-(3,6,9,12,15,18-hexaoxahenicos-20-yn-1-yl)-2,5-pyrroledione

3,6,9,12,15,18-hexaoxahenicos-20-yn-1-yl p-toluenesulfonate

C₂₂H₃₁NO₁₁

ω-propynyl-3,6,9,12,15,18-hexaoxahenicos-1-amine