[(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]diphenylmethanol

Base Information

• Chemical Name: [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]diphenylmethanol
• CAS No.: 607405-08-3
• Molecular Formula: C₂₇H₂₉NO₃S
• Molecular Weight: 447.598

Synonyms:[(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]diphenylmethanol

Chemical Property of [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]diphenylmethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]diphenylmethanol

There total 3 articles about [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]diphenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

phenylmagnesium bromide + methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide (607405-07-2) → [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]diphenylmethanol (607405-08-3)

Guidance literature:

In tetrahydrofuran; diethyl ether; for 5h;

DOI:10.1002/ejoc.200300172

Reference yield:

methyl 2,5-dihydrothiophene-S,S-dioxide-3-carboxylate (67488-50-0) → [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]diphenylmethanol (607405-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

2: 62 percent / tetrahydrofuran; diethyl ether / 5 h

With trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1002/ejoc.200300172

Reference yield:

(R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine (133407-38-2) → [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]diphenylmethanol (607405-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / trifluoroacetic acid / CH₂Cl₂ / 0.5 h / 20 °C

2: 62 percent / tetrahydrofuran; diethyl ether / 5 h

With trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1002/ejoc.200300172

upstream raw materials:

methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide

methyl 2,5-dihydrothiophene-S,S-dioxide-3-carboxylate

(R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine

Downstream raw materials:

(3aS,6aR)-3a-[(methoxy)diphenylmethyl]-5-[(1R)-1-phenylethyl]hexahydro-1H-thieno[3,4-c]pyrrole 2,2-dioxide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 607405-08-3 [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]diphenylmethanol

Send

Send

Metric Ton KG G Pound L ML

Send

Send