methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide

Base Information

• Chemical Name: methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide
• CAS No.: 607405-07-2
• Molecular Formula: C₁₆H₂₁NO₄S
• Molecular Weight: 323.413

Synonyms:methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide

Chemical Property of methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide

Chemical Property:

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Technology Process of methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide

There total 1 articles about methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

methyl 2,5-dihydrothiophene-S,S-dioxide-3-carboxylate (67488-50-0) + (R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine (133407-38-2) → methyl (3aR,6aS)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide + methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide (607405-07-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/ejoc.200300172

Reference yield: 62.0%

phenylmagnesium bromide + methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide (607405-07-2) → [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]diphenylmethanol (607405-08-3)

Guidance literature:

In tetrahydrofuran; diethyl ether; for 5h;

DOI:10.1002/ejoc.200300172

Reference yield: 62.0%

4-methoxyphenyl magnesium bromide (13139-86-1) + methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide (607405-07-2) → [(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]bis(4-methoxyphenyl)methanol (607405-09-4)

Guidance literature:

In tetrahydrofuran; diethyl ether; for 5h;

DOI:10.1002/ejoc.200300172

upstream raw materials:

methyl 2,5-dihydrothiophene-S,S-dioxide-3-carboxylate

(R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine

Downstream raw materials:

[(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]diphenylmethanol

[(3aS,6aR)-2,2-dioxido-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrol-3a(3H)-yl]bis(4-methoxyphenyl)methanol

(3aS,6aR)-3a-[(methoxy)diphenylmethyl]-5-[(1R)-1-phenylethyl]hexahydro-1H-thieno[3,4-c]pyrrole 2,2-dioxide

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