SODIUM PHENOTHIAZINE-10-YL-PROPYLSULFONATE

Base Information

• Chemical Name: SODIUM PHENOTHIAZINE-10-YL-PROPYLSULFONATE
• CAS No.: 101199-38-6
• Molecular Formula: C15H14NNaO3S2
• Molecular Weight: 343.403
• Hs Code.: 2934999090
• Mol file: 101199-38-6.mol

Synonyms:10H-Phenothiazine-10-propanesulfonicacid, sodium salt (9CI);

Chemical Property of SODIUM PHENOTHIAZINE-10-YL-PROPYLSULFONATE

Chemical Property:

• PSA: 94.12000
• LogP: 4.37040
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Heated)

Purity/Quality:

>98% ^*data from raw suppliers

Sodium3-?(10H-?Phenothiazin-?10-?yl)?propane-?1-?sulfonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Sodium 3-?(10H-?Phenothiazin-?10-?yl)?propane-?1-?sulfonate can be used in biological and analytical studies of a portable chemiluminescence imaging immunoassay for simultaneous detection of different isoforms of prostate specific antigen in serum.

Technology Process of SODIUM PHENOTHIAZINE-10-YL-PROPYLSULFONATE

There total 6 articles about SODIUM PHENOTHIAZINE-10-YL-PROPYLSULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.9%

1,3-propanesultone (1120-71-4) + 10H-phenothiazine (92-84-2) → sodium 3-(10'-phenothiazinyl)propane-1-sulfonate (101199-38-6)

Guidance literature:

10H-phenothiazine; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 - 50 ℃; for 1.5h; Inert atmosphere;

1,3-propanesultone; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1h;

Reference yield: 51.0%

10-(3-bromopropyl)phenothiazine (92357-95-4) → sodium 3-(10'-phenothiazinyl)propane-1-sulfonate (101199-38-6)

Guidance literature:

With sodium sulfite; In water; acetonitrile; for 12h; Heating;

DOI:10.1021/j100402a041

Reference yield:

1,3-propanesultone (1120-71-4) + phenothiazine sodium salt → sodium 3-(10'-phenothiazinyl)propane-1-sulfonate (101199-38-6)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 1h;

upstream raw materials:

10H-phenothiazine

1,3-dibromo-propane

10-(3-bromopropyl)phenothiazine

1,3-propanesultone

Downstream raw materials:

methyl viologen radical cation chloride

Refernces

• 1、 -. "Preparation of high purity phenothiazine N-alkylsulfonates and their use in chemiluminescent assays for the measurement of peroxidase activity". Page/Page column 5. . Retrieved 2010/12/31.
• 2、 -. "Preparation of high purity phenothiazine n-alkylsulfonates and their use in chemiluminescent assays for the measurement of peroxidase activity". Page/Page column 4-5. . Retrieved 2008/12/07.