N-p-Methoxyphenylpropiolamide

Base Information

• Chemical Name: N-p-Methoxyphenylpropiolamide
• CAS No.: 124791-83-9
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.187
• Mol file: 124791-83-9.mol

Synonyms:N-p-Methoxyphenylpropiolamide

Chemical Property of N-p-Methoxyphenylpropiolamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-p-Methoxyphenylpropiolamide

There total 2 articles about N-p-Methoxyphenylpropiolamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-methoxy-aniline (104-94-9) + propynoic acid ethyl ester (623-47-2) → N-p-Methoxyphenylpropiolamide (124791-83-9)

Guidance literature:

Candida cylindracea lipase; In tetrachloromethane; at 25 ℃; for 72h;

DOI:10.1016/S0040-4039(01)93782-7

Reference yield: 83.6%

→ N-p-Methoxyphenylpropiolamide (124791-83-9)

Guidance literature:

With benzotriazol-1-ol; N-[3-(N,N-dimethylamino)-propyl]-N'-ethyl-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 ℃;

Reference yield: 44.0%

4-toluenesulfonyl azide (941-55-9) + N-p-Methoxyphenylpropiolamide (124791-83-9) + 4-methyl-N-phenyl-benzamidine (7118-55-0) → (Z)-3-amino-N-(4-methoxyphenyl)-2-((Z)-N-phenyl-N'-tosylcarbamimidoyl)-3-(p-tolyl)acrylamide

Guidance literature:

With copper(I) bromide; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.joc.5b00827

upstream raw materials:

4-methoxy-aniline

propynoic acid ethyl ester

Downstream raw materials:

C₁₅H₁₇NO₂

C₁₅H₁₇NO₂