methyl 6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoate

Base Information

Chemical Name:methyl 6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoate
CAS No.:871927-80-9
Molecular Formula:C₂₉H₂₆O₂
Molecular Weight:406.524
Hs Code.:

Synonyms:methyl 6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoate

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Chemical Property of methyl 6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoate

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Technology Process of methyl 6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoate

There total 8 articles about methyl 6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 303142-41-8
methyl 6-(3-iodophenyl)-5-hexynoate

: 303142-40-7
1-(1-ethynyl)-2-(2-phenyl-1-ethynyl)-1-cyclohexene

: 871927-80-9
methyl 6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoate

Guidance literature:: With copper(l) iodide; triethylamine; bis(triphenylphosphine)palladium⁽⁰⁾; for 4h;
DOI:10.1021/jo051403q

Reference yield:

: 77758-51-1
methyl hex-5-ynoate

: 871927-80-9
methyl 6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoate

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / n-butylamine; CuI / PdCl₂(PPh₃)2 / diethyl ether / 4 h / 0 - 20 °C

2: 94 percent / triethylamine; CuI / Pd(PPh₃)2 / 4 h

With copper(l) iodide; N-butylamine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; bis(triphenylphosphine)palladium⁽⁰⁾; In diethyl ether;
DOI:10.1021/jo051403q

Reference yield:

: 1-phenyl-10-(1,1,1-triisopropylsilyl)-1,9-decadiyne-3,8-dione

: 871927-80-9
methyl 6-(3-(2-[2-(2-phenyl-1-ethynyl)-1-cyclohexenyl]-1-ethynyl)-phenyl)-5-hexynoate

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / NaBH₄ / methanol / 0.5 h / -15 - 20 °C

2: 82 percent / triphenylphosphine; Br₂; 2,6-lutidine / CH₂Cl₂ / 2 h / 0 - 10 °C

3: 94 percent / LiHMDS; hexamethylphosphoramide / tetrahydrofuran / 2.25 h / -78 °C

4: 85 percent / tetrabutylammonium fluoride / tetrahydrofuran / 20 h / 0 °C

5: 94 percent / triethylamine; CuI / Pd(PPh₃)2 / 4 h

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; copper(l) iodide; tetrabutyl ammonium fluoride; bromine; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; bis(triphenylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo051403q