5-[(dimethylamino)methyl]-N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Base Information

Chemical Name:5-[(dimethylamino)methyl]-N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine
CAS No.:1187669-02-8
Molecular Formula:C₁₈H₂₀N₄S
Molecular Weight:324.45
Hs Code.:

Synonyms:5-[(dimethylamino)methyl]-N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

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Chemical Property of 5-[(dimethylamino)methyl]-N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Chemical Property:

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Technology Process of 5-[(dimethylamino)methyl]-N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

There total 8 articles about 5-[(dimethylamino)methyl]-N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₇N₃O₃S₂

: 74-89-5
methylamine

: 1187669-02-8
5-[(dimethylamino)methyl]-N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Guidance literature:: In water; N,N-dimethyl-formamide; at 80 ℃; for 4h;

Reference yield:

: 315702-99-9
N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

: 1187669-02-8
5-[(dimethylamino)methyl]-N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran; water / 1 h / 130 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

3: water; N,N-dimethyl-formamide / 4 h / 80 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 108-44-1
1-amino-3-methylbenzene

: 1187669-02-8
5-[(dimethylamino)methyl]-N-(3-methylphenyl)-4-(4-pyridinyl)-1,3-thiazol-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzoyl chloride / acetone / Heating; Reflux

1.2: 20 °C / Heating; Reflux; Cooling with ice

1.3: 80 °C / pH 10 / Cooling with ice

2.1: ethanol / 3 h / Heating; Reflux

2.2: 2 h / 20 °C / pH ~ 8

3.1: triethylamine / tetrahydrofuran; water / 1 h / 130 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

5.1: water; N,N-dimethyl-formamide / 4 h / 80 °C

With benzoyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; 2.1: Hantzsch thiazole synthesis;