(S)-N-{{3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

Base Information

Chemical Name:(S)-N-{{3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide
CAS No.:1214265-41-4
Molecular Formula:C₂₀H₂₃F₂N₃O₅
Molecular Weight:423.417
Hs Code.:

Synonyms:(S)-N-{{3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

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Chemical Property of (S)-N-{{3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

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Technology Process of (S)-N-{{3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

There total 10 articles about (S)-N-{{3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1214265-40-3
(R)-{N-3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl azide

: 64-19-7,77671-22-8
acetic acid

: 1214265-41-4
(S)-N-{{3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

Guidance literature:: (R)-{N-3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl azide; With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 14h; under 760.051 Torr;

acetic acid; With pyridine; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: C₁₈H₂₁F₂N₃O₄

: 64-19-7,77671-22-8
acetic acid

: 1214265-41-4
(S)-N-{{3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

Guidance literature:: With pyridine; at 0 - 20 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 1214265-35-6
3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)-nitrobenzene

: 1214265-41-4
(S)-N-{{3-[3,5-difluoro-4-(7,7-ethylenedioxy-5-azaspiro[2,4]heptan-5-yl)phenyl]-2-oxo-5-oxazolidinyl}methyl}acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 2 h / 2068.65 Torr

2.1: sodium hydrogencarbonate / water; acetone / 20 °C / Ice bath

3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

3.2: -78 - 20 °C

4.1: triethylamine / dichloromethane / 20 °C / Ice bath

5.1: sodium azide / N,N-dimethyl-formamide / 16 h / 60 °C

6.1: hydrogen / palladium on activated charcoal / ethyl acetate / 14 h / 20 °C / 760.05 Torr

7.1: pyridine / 2.5 h / 0 - 20 °C / Inert atmosphere

With pyridine; n-butyllithium; sodium azide; hydrogen; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; hexane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;