4-{Formyl-[(E)-1-(toluene-4-sulfonylmethyl)-but-1-enyl]-amino}-isophthalic acid dimethyl ester

Base Information

• Chemical Name: 4-{Formyl-[(E)-1-(toluene-4-sulfonylmethyl)-but-1-enyl]-amino}-isophthalic acid dimethyl ester
• CAS No.: 514805-26-6
• Molecular Formula: C₂₃H₂₅NO₇S
• Molecular Weight: 459.52
• Mol file: 514805-26-6.mol

Synonyms:4-{Formyl-[(E)-1-(toluene-4-sulfonylmethyl)-but-1-enyl]-amino}-isophthalic acid dimethyl ester

Chemical Property of 4-{Formyl-[(E)-1-(toluene-4-sulfonylmethyl)-but-1-enyl]-amino}-isophthalic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-{Formyl-[(E)-1-(toluene-4-sulfonylmethyl)-but-1-enyl]-amino}-isophthalic acid dimethyl ester

There total 4 articles about 4-{Formyl-[(E)-1-(toluene-4-sulfonylmethyl)-but-1-enyl]-amino}-isophthalic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 4-{Formyl-[(E)-1-(toluene-4-sulfonylmethyl)-but-1-enyl]-amino}-3-iodo-benzoic acid methyl ester (514805-27-7) → 4-{Formyl-[(E)-1-(toluene-4-sulfonylmethyl)-but-1-enyl]-amino}-isophthalic acid dimethyl ester (514805-26-6)

Guidance literature:

With triethylamine; palladium diacetate; at 70 ℃; for 48h; under 20520 Torr;

DOI:10.1021/jo026595t

Reference yield:

4-amino-3-iodobenzoic acid methyl ester (19718-49-1) → 4-{Formyl-[(E)-1-(toluene-4-sulfonylmethyl)-but-1-enyl]-amino}-isophthalic acid dimethyl ester (514805-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / 4 h / Heating

2: 83 percent / triethylamine / Pd(OAc)2 / 16 h / 60 °C / 20520 Torr

3: potassium carbonate / dimethylformamide; H₂O / 96 h / 20 °C

With potassium carbonate; triethylamine; palladium diacetate; In water; N,N-dimethyl-formamide;

DOI:10.1021/jo026595t

Reference yield:

4-formylamino-3-iodo-benzoic acid methyl ester (514805-23-3) → 4-{Formyl-[(E)-1-(toluene-4-sulfonylmethyl)-but-1-enyl]-amino}-isophthalic acid dimethyl ester (514805-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / triethylamine / Pd(OAc)2 / 16 h / 60 °C / 20520 Torr

2: potassium carbonate / dimethylformamide; H₂O / 96 h / 20 °C

With potassium carbonate; triethylamine; palladium diacetate; In water; N,N-dimethyl-formamide;

DOI:10.1021/jo026595t

upstream raw materials:

methanol

carbon monoxide

4-{Formyl-[(E)-1-(toluene-4-sulfonylmethyl)-but-1-enyl]-amino}-3-iodo-benzoic acid methyl ester

1-(p-toluenesulfonyl)-1-pentyne