1H-Benzimidazole,1,5-dimethyl-(9CI)

Base Information

• Chemical Name: 1H-Benzimidazole,1,5-dimethyl-(9CI)
• CAS No.: 10394-35-1
• Molecular Formula: C9H10 N2
• Molecular Weight: 146.192
• Hs Code.: 2933990090
• Mol file: 10394-35-1.mol

Synonyms:Benzimidazole,1,5-dimethyl- (8CI); 1,5-Dimethylbenzimidazole

Chemical Property of 1H-Benzimidazole,1,5-dimethyl-(9CI)

Chemical Property:

• Melting Point: 95°C
• Refractive Index: 1.5600 (estimate)
• Boiling Point: 255.81°C (rough estimate)
• PKA: 5.71±0.10(Predicted)
• PSA: 17.82000
• Density: 1.0976 (rough estimate)
• LogP: 1.88170

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,5-DIMETHYL-1H-BENZIMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Benzimidazole,1,5-dimethyl-(9CI)

There total 14 articles about 1H-Benzimidazole,1,5-dimethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

orthoformic acid triethyl ester (122-51-0) + 2-amino-4-methyl-N-methylaminobenzene (39513-19-4) → 1,5-dimethylbenzimidazole (10394-35-1)

Guidance literature:

With ammonium chloride; In ethanol; at 110 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02346

Reference yield: 73.0%

methanol (67-56-1) + 4-methyl-2-nitroaniline (89-62-3) → 1,6-dimethylbenzimidazole (10394-40-8) + 1,5-dimethylbenzimidazole (10394-35-1) + 5-methylbenzimidazole (614-97-1)

Guidance literature:

With Cu-Zn-PMO; at 250 ℃; for 3h; Sealed tube; Supercritical conditions; Green chemistry;

DOI:10.1039/c5gc01040c

Reference yield: 60.0%

methanol (67-56-1) + 4-methyl-1,2-diaminobenzene (496-72-0) → 1,6-dimethylbenzimidazole (10394-40-8) + 1,5-dimethylbenzimidazole (10394-35-1) + 5-methylbenzimidazole (614-97-1)

Guidance literature:

With Cu-PMO (copper-doped porous metal oxide); at 250 ℃; for 6h; Supercritical conditions; Sealed tube; Green chemistry;

DOI:10.1039/c5gc01040c

upstream raw materials:

5-methylbenzimidazole

dimethyl sulfate

4,N,N-trimethyl-2-nitroaniline

formic acid

Downstream raw materials:

1-methylbenzimidazole-5-carboxylic acid hydrochloride

C₁₇H₁₆N₂

C₁₅H₁₃FN₂

C₁₆H₁₆N₂O

Refernces

• 1、 Sun, Zhuohua,Bottari, Giovanni,Barta, Katalin. "Supercritical methanol as solvent and carbon source in the catalytic conversion of 1,2-diaminobenzenes and 2-nitroanilines to benzimidazoles". . p. 5172 - 5181. Retrieved 2015/12/08.