1,1,2-Tris(4-methoxyphenyl)ethan-1-ol

Base Information

• Chemical Name: 1,1,2-Tris(4-methoxyphenyl)ethan-1-ol
• CAS No.: 1817-87-4
• Molecular Formula: C23H24 O4
• Molecular Weight: 364.441
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID30600436
• Wikidata: Q82496517
• Mol file: 1817-87-4.mol

Synonyms:1,1,2-Tris(4-methoxyphenyl)ethan-1-ol;1817-87-4;1,1,2-TRIS(4-METHOXYPHENYL)ETHANOL;SCHEMBL9839441;DTXSID30600436;XZKJJZRDNXWVLH-UHFFFAOYSA-N

Chemical Property of 1,1,2-Tris(4-methoxyphenyl)ethan-1-ol

Chemical Property:

• PSA: 47.92000
• LogP: 4.19100
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 364.16745924
• Heavy Atom Count: 27
• Complexity: 392

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)O

Technology Process of 1,1,2-Tris(4-methoxyphenyl)ethan-1-ol

There total 7 articles about 1,1,2-Tris(4-methoxyphenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methoxybenzene (100-66-3) → 1,1,2-tris-(4-methoxy-phenyl)-ethanol (1817-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / AlCl₃ / 1,2-dichloro-ethane / 2 h / Heating

2: tetrahydrofuran / 12 h / Heating

With aluminium trichloride; In tetrahydrofuran; 1,2-dichloro-ethane; 2: Grignard reaction;

DOI:10.1021/jm0210562

Reference yield:

4-methoxyphenyl-acetic chloride (4693-91-8) → 1,1,2-tris-(4-methoxy-phenyl)-ethanol (1817-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / AlCl₃ / 1,2-dichloro-ethane / 2 h / Heating

2: tetrahydrofuran / 12 h / Heating

With aluminium trichloride; In tetrahydrofuran; 1,2-dichloro-ethane; 2: Grignard reaction;

DOI:10.1021/jm0210562

Reference yield:

1,4-di(4-methoxyphenyl)ethanone (120-44-5) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 1,1,2-tris-(4-methoxy-phenyl)-ethanol (1817-87-4)

Guidance literature:

In tetrahydrofuran; for 12h; Heating;

DOI:10.1021/jm0210562

upstream raw materials:

ethyl p-methoxyphenylacetate

4-methoxyphenyl magnesium bromide

bis(p-methoxyphenyl)methanone

1,4-di(4-methoxyphenyl)ethanone

Downstream raw materials:

1-bromo-1,2,2-tris(p-methoxyphenyl)ethene

1,1,2-tris(4-methoxyphenyl)ethene

4,4',4''-ethenetriyl-tri-phenol

chlorotrianisene