(2-amino-3-nitro-6-trifluoromethylpyridin-4-yl)benzylcarbamic acid ethyl ester

Base Information

Chemical Name:(2-amino-3-nitro-6-trifluoromethylpyridin-4-yl)benzylcarbamic acid ethyl ester
CAS No.:947144-34-5
Molecular Formula:C₁₆H₁₅F₃N₄O₄
Molecular Weight:384.315
Hs Code.:

Synonyms:(2-amino-3-nitro-6-trifluoromethylpyridin-4-yl)benzylcarbamic acid ethyl ester

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Chemical Property of (2-amino-3-nitro-6-trifluoromethylpyridin-4-yl)benzylcarbamic acid ethyl ester

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Technology Process of (2-amino-3-nitro-6-trifluoromethylpyridin-4-yl)benzylcarbamic acid ethyl ester

There total 6 articles about (2-amino-3-nitro-6-trifluoromethylpyridin-4-yl)benzylcarbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 947144-36-7
benzyl-(2-chloro-3-nitro-6-trifluoromethylpyridin-4-yl)carbamic acid ethyl ester

: 947144-34-5
(2-amino-3-nitro-6-trifluoromethylpyridin-4-yl)benzylcarbamic acid ethyl ester

Guidance literature:: With ammonia; In tetrahydrofuran; water; at 80 ℃; for 2h; Sealed vessel;

Reference yield:

: 947144-32-3
4-hydroxy-6-(trifluoromethyl)pyridin-2(1H)-one

: 947144-34-5
(2-amino-3-nitro-6-trifluoromethylpyridin-4-yl)benzylcarbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; nitric acid / 5.5 h / 20 - 50 °C

2.1: P,P-dichlorophenylphosphine oxide / dichloromethane / 15 h / 95 °C / Inert atmosphere; Large scale reaction

3.1: tetrahydrofuran / 22 h / Reflux; Large scale reaction

4.1: P,P-dichlorophenylphosphine oxide / dichloromethane / 22 h / 95 °C / Inert atmosphere; Large scale reaction

5.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / -10 - -8 °C / Inert atmosphere; Large scale reaction

5.2: 1.5 h / -10 - -7 °C

6.1: ammonia / tetrahydrofuran / 41 h / 45 - 50 °C / Large scale reaction

With P,P-dichlorophenylphosphine oxide; sulfuric acid; potassium tert-butylate; ammonia; nitric acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/op200021a

Reference yield:

: 947144-26-5
4-hydroxy-3-nitro-6-trifluoromethyl-1H-pyridin-2-one

: 947144-34-5
(2-amino-3-nitro-6-trifluoromethylpyridin-4-yl)benzylcarbamic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: P,P-dichlorophenylphosphine oxide / dichloromethane / 15 h / 95 °C / Inert atmosphere; Large scale reaction

2.1: tetrahydrofuran / 22 h / Reflux; Large scale reaction

3.1: P,P-dichlorophenylphosphine oxide / dichloromethane / 22 h / 95 °C / Inert atmosphere; Large scale reaction

4.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / -10 - -8 °C / Inert atmosphere; Large scale reaction

4.2: 1.5 h / -10 - -7 °C

5.1: ammonia / tetrahydrofuran / 41 h / 45 - 50 °C / Large scale reaction

With P,P-dichlorophenylphosphine oxide; potassium tert-butylate; ammonia; In tetrahydrofuran; dichloromethane;
DOI:10.1021/op200021a