5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-phenyl-furo[3,2-h]quinolin-9-ium bromide

Base Information

• Chemical Name: 5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-phenyl-furo[3,2-h]quinolin-9-ium bromide
• CAS No.: 1436840-89-9
• Molecular Formula: Br*C₂₅H₁₇ClNO₂
• Molecular Weight: 478.772
• Mol file: 1436840-89-9.mol

Synonyms:5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-phenyl-furo[3,2-h]quinolin-9-ium bromide

Chemical Property of 5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-phenyl-furo[3,2-h]quinolin-9-ium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-phenyl-furo[3,2-h]quinolin-9-ium bromide

There total 1 articles about 5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-phenyl-furo[3,2-h]quinolin-9-ium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

5-chloro-2-phenylfuro[3,2-h]quinoline (1218818-87-1) + α-bromoacetophenone (70-11-1) → 5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-phenyl-furo[3,2-h]quinolin-9-ium bromide (1436840-89-9)

Guidance literature:

With basic alumina; at 90 ℃; Microwave irradiation;

DOI:10.2174/15701808113109990046

Reference yield: 95.0%

5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-phenyl-furo[3,2-h]quinolin-9-ium bromide (1436840-89-9) + propynoic acid ethyl ester (623-47-2) → 10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylicacid ethyl ester (1436841-28-9)

Guidance literature:

With aluminum oxide; In chloroform; at 90 ℃; Microwave irradiation; Green chemistry;

DOI:10.1016/j.tetlet.2013.03.095

Reference yield: 94.0%

N-(4-methoxyphenyl)maleimide (1081-17-0) + 5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-phenyl-furo[3,2-h]quinolin-9-ium bromide (1436840-89-9) → C36H25ClN2O5

Guidance literature:

N-(4-methoxyphenyl)maleimide; 5-chloro-9-(2-oxo-2-phenyl-ethyl)-2-phenyl-furo[3,2-h]quinolin-9-ium bromide; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 0.5h;

With 1,7-phenanthroline; copper dichloride; In acetonitrile; at 65 ℃; for 3h; Reagent/catalyst; Solvent; Temperature; Time; regioselective reaction;

DOI:10.3762/bjoc.10.62

upstream raw materials:

5-chloro-2-phenylfuro[3,2-h]quinoline

α-bromoacetophenone

Downstream raw materials:

10-benzoyl-5-chloro-2-phenyl-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylic acid methyl ester

10-benzoyl-5-chloro-2-(4-fluoro-phenyl)-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8-carboxylicacid ethyl ester

10-benzoyl-5-chloro-2-phenyl-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8,9-dicarboxylic acid dimethyl ester

10-benzoyl-5-chloro-2-phenyl-1-oxa-10a-aza-dicyclopenta[a,h]naphthalene-8,9-dicarboxylic acid diethyl ester