Technology Process of 2-bromo-6-(1-oxo-3,4,6,7,8,9-hexahydropyrido[3,4-b]imidazo[4,5-c]pyridine-2-yl)benzyl acetate
There total 8 articles about 2-bromo-6-(1-oxo-3,4,6,7,8,9-hexahydropyrido[3,4-b]imidazo[4,5-c]pyridine-2-yl)benzyl acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
acetic acid 2,6-dibromobenzyl ester; 3,4,6,7,8,9-hexahydropyrido[3,4-b]imidazo[4,5-c]pyridine-1-one;
With
caesium carbonate;
copper(l) iodide;
In
1-methyl-pyrrolidin-2-one;
at 120 ℃;
for 16h;
Inert atmosphere;
acetyl chloride;
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 14 h / 80 °C / Inert atmosphere
2.1: N,N-dimethyl-formamide / 14 h / 20 °C / Inert atmosphere
3.1: caesium carbonate / copper(l) iodide / 1-methyl-pyrrolidin-2-one / 16 h / 120 °C / Inert atmosphere
3.2: 2 h / 20 °C
With
N-Bromosuccinimide; caesium carbonate;
copper(l) iodide; 2,2'-azobis(isobutyronitrile);
In
1-methyl-pyrrolidin-2-one; tetrachloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: ethanol / 2 h / 70 °C / Inert atmosphere
2.1: triethyl phosphite / 24 h / 110 °C / Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 0 - 20 °C
4.1: acetic anhydride / 1.5 h / 140 °C / Inert atmosphere
5.1: hydrogen; acetic acid / palladium 10% on activated carbon / 48 h / 85 °C / 18100.7 Torr
5.2: pH 9
6.1: caesium carbonate / copper(l) iodide / 1-methyl-pyrrolidin-2-one / 16 h / 120 °C / Inert atmosphere
6.2: 2 h / 20 °C
With
hydrogen; acetic anhydride; caesium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; triethyl phosphite;
copper(l) iodide; palladium 10% on activated carbon;
In
1-methyl-pyrrolidin-2-one; ethanol; dichloromethane;
