2-(4-{3-[4-(2,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid methyl ester

Base Information

Chemical Name:2-(4-{3-[4-(2,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid methyl ester
CAS No.:425672-76-0
Molecular Formula:C₂₅H₃₁N₃O₆
Molecular Weight:469.538
Hs Code.:

Synonyms:2-(4-{3-[4-(2,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid methyl ester

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Chemical Property of 2-(4-{3-[4-(2,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(4-{3-[4-(2,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid methyl ester

There total 6 articles about 2-(4-{3-[4-(2,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20637-08-5
4-(4-methoxyphenyl)butyric acid methyl ester

: 425672-76-0
2-(4-{3-[4-(2,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: BBr₃ / CH₂Cl₂ / 1 h / 0 °C

2: 27 g / K₂CO₃; MgSO₄ / dimethylformamide / 75 °C

3: hydrazine hydrate / methanol / 20 °C

4: 67 percent / CH₂Cl₂ / 2 h / 20 °C

5: KOH / methanol / 48 h / Heating

6: H₂SO₄ / 4 h / 35 °C

With potassium hydroxide; sulfuric acid; boron tribromide; magnesium sulfate; potassium carbonate; hydrazine hydrate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm034173l

Reference yield:

: 22320-10-1
methyl 4-(4-hydroxyphenyl)butanoate

: 425672-76-0
2-(4-{3-[4-(2,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 27 g / K₂CO₃; MgSO₄ / dimethylformamide / 75 °C

2: hydrazine hydrate / methanol / 20 °C

3: 67 percent / CH₂Cl₂ / 2 h / 20 °C

4: KOH / methanol / 48 h / Heating

5: H₂SO₄ / 4 h / 35 °C

With potassium hydroxide; sulfuric acid; magnesium sulfate; potassium carbonate; hydrazine hydrate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm034173l

Reference yield:

: 425672-61-3
4-[4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)phenyl]butyric acid methyl ester

: 425672-76-0
2-(4-{3-[4-(2,4-dimethoxybenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / methanol / 20 °C

2: 67 percent / CH₂Cl₂ / 2 h / 20 °C

3: KOH / methanol / 48 h / Heating

4: H₂SO₄ / 4 h / 35 °C

With potassium hydroxide; sulfuric acid; hydrazine hydrate; In methanol; dichloromethane;
DOI:10.1021/jm034173l