(2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

Base Information

Chemical Name:(2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid
CAS No.:1581735-07-0
Molecular Formula:C₁₄H₂₁F₃O₄
Molecular Weight:310.314
Hs Code.:

Synonyms:(2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

Suppliers and Price of (2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
Butanedioicacid,2-(2-propen-1-yl)-3-(3,3,3-trifluoropropyl)-,1-(1,1-dimethylethyl)ester,(2S,3R)-
1g
$ 1400.00

Total 2 raw suppliers

Chemical Property of (2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Butanedioicacid,2-(2-propen-1-yl)-3-(3,3,3-trifluoropropyl)-,1-(1,1-dimethylethyl)ester,(2S,3R)- ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

There total 7 articles about (2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1401067-08-0
(R)-2-(2-(tert-butoxy)-2-oxoethyl)-5,5,5-trifluoropentanoic acid

: 106-95-6
allyl bromide

: 1581735-07-0
(2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

: 1581735-08-1
(2R,3R)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

Guidance literature:: (R)-2-(2-(tert-butoxy)-2-oxoethyl)-5,5,5-trifluoropentanoic acid; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

allyl bromide; In tetrahydrofuran; hexane; at 20 ℃; Overall yield = 100 %; Overall yield = 16.8 g;

Reference yield:

: (2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

: 1581735-07-0
(2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

: 1581735-08-1
(2R,3R)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

Guidance literature:: (2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 - 20 ℃; for 0.75h;

With diethylaluminium chloride; In tetrahydrofuran; hexane; n-heptane; ethylbenzene; at -78 - 20 ℃; for 0.666667h; Overall yield = 100 %; Overall yield = 10 g;

Reference yield:

: 1401065-46-0
(4S)-4-benzyl-3-(5,5,5-trifluoropentanoyl)-1,3-oxazolidin-2-one

: 1581735-07-0
(2R,3S)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

: 1581735-08-1
(2R,3R)-3-(tert-butoxycarbonyl)-2-(3,3,3-trifluoropropyl)hex-5-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

1.2: 6 h / -78 °C / Inert atmosphere

2.1: lithium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 1.17 h / 0 - 20 °C

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 2 h / -78 - -72 °C

3.2: -78 - 20 °C

With dihydrogen peroxide; sodium hexamethyldisilazane; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; hexane; water;