Technology Process of UN(107)C10957A
There total 11 articles about UN(107)C10957A which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yloxy)butyl methanesulfonate;
With
sodium iodide;
In
acetonitrile;
for 0.5h;
Reflux;
1-(2-methoxyphenyl)piperazine hydrochloride;
With
potassium carbonate;
In
acetonitrile;
for 4h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: triethylamine / dichloromethane / 20 °C / Cooling with ice
2.1: n-butyllithium / tetrahydrofuran / 3 h / -20 °C
2.2: -20 - 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
4.1: sodium hydride / tetrahydrofuran / Inert atmosphere; Cooling with ice
4.2: Reflux
5.1: hydrogen / Raney nickel / tetrahydrofuran
6.1: hydrogenchloride / 1,4-dioxane / 3 h / Reflux
6.2: 20 °C / pH 8
7.1: hydrogen / palladium 10% on activated carbon / ethanol
8.1: triethylamine / dichloromethane / 6 h / 20 °C
9.1: sodium iodide / acetonitrile / 0.5 h / Reflux
9.2: 4 h / Reflux
With
hydrogenchloride; n-butyllithium; hydrogen; sodium hydride; triethylamine; sodium iodide;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: n-butyllithium / tetrahydrofuran / 3 h / -20 °C
1.2: -20 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C
3.1: sodium hydride / tetrahydrofuran / Inert atmosphere; Cooling with ice
3.2: Reflux
4.1: hydrogen / Raney nickel / tetrahydrofuran
5.1: hydrogenchloride / 1,4-dioxane / 3 h / Reflux
5.2: 20 °C / pH 8
6.1: hydrogen / palladium 10% on activated carbon / ethanol
7.1: triethylamine / dichloromethane / 6 h / 20 °C
8.1: sodium iodide / acetonitrile / 0.5 h / Reflux
8.2: 4 h / Reflux
With
hydrogenchloride; n-butyllithium; hydrogen; sodium hydride; triethylamine; sodium iodide;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
