2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole

Base Information

Chemical Name:2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole
CAS No.:1021736-30-0
Molecular Formula:C₂₈H₂₅F₃N₂
Molecular Weight:446.515
Hs Code.:

Synonyms:2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole

Suppliers and Price of 2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Technology Process of 2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole

There total 4 articles about 2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1022154-58-0
(2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone

: 1021736-30-0
2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole

Guidance literature:: With potassium hydroxide; hydrazine hydrate; In water; diethylene glycol; at 20 - 155 ℃; Large scale reaction;
DOI:10.1021/op9000274

Reference yield:

: 1011460-56-2
1-trifluoromethyl-cyclopropanecarboxylic acid methoxy-methyl amide

: 1021736-30-0
2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethylmagnesium bromide / diethyl ether; dichloromethane / 0.5 h / 5 °C

1.2: 19 h / 20 °C

2.1: hydrazine hydrate; potassium hydroxide / ethylene glycol / 2.33 h / 120 - 180 °C

With ethylmagnesium bromide; hydrazine hydrate; potassium hydroxide; In diethyl ether; dichloromethane; ethylene glycol;
DOI:10.1021/ml100196d

Reference yield:

: 157255-72-6
4-iodo-2-methyl-1-triphenylmethylimidazole

: 1021736-30-0
2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethylmagnesium bromide / diethyl ether; dichloromethane / 0.5 h / 5 °C

1.2: 19 h / 20 °C

2.1: hydrazine hydrate; potassium hydroxide / ethylene glycol / 2.33 h / 120 - 180 °C

With ethylmagnesium bromide; hydrazine hydrate; potassium hydroxide; In diethyl ether; dichloromethane; ethylene glycol;
DOI:10.1021/ml100196d