(2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone

Base Information

Chemical Name:(2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone
CAS No.:1022154-58-0
Molecular Formula:C₂₈H₂₃F₃N₂O
Molecular Weight:460.499
Hs Code.:

Synonyms:(2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone

Suppliers and Price of (2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone

There total 3 articles about (2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1011460-56-2
1-trifluoromethyl-cyclopropanecarboxylic acid methoxy-methyl amide

: 96797-15-8
N-trityl-4⁽⁵⁾-iodoimidazole

: 1022154-58-0
(2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone

Guidance literature:: N-trityl-4⁽⁵⁾-iodoimidazole; With ethylmagnesium bromide; In dichloromethane; at 5 - 25 ℃; Large scale reaction;

1-trifluoromethyl-cyclopropanecarboxylic acid methoxy-methyl amide; In dichloromethane; at 20 ℃; for 15h; Large scale reaction;
DOI:10.1021/op9000274

Reference yield:

: 1011460-56-2
1-trifluoromethyl-cyclopropanecarboxylic acid methoxy-methyl amide

: 157255-72-6
4-iodo-2-methyl-1-triphenylmethylimidazole

: 1022154-58-0
(2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone

Guidance literature:: 4-iodo-2-methyl-1-triphenylmethylimidazole; With ethylmagnesium bromide; In diethyl ether; dichloromethane; at 5 ℃; for 1.5h;

1-trifluoromethyl-cyclopropanecarboxylic acid methoxy-methyl amide; In diethyl ether; dichloromethane; at 12 - 20 ℃;

Reference yield:

: 277756-46-4
1-(trifluoromethyl)cyclopropanecarboxylic acid

: 1022154-58-0
(2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2.1: ethylmagnesium bromide / diethyl ether; dichloromethane / 0.5 h / 5 °C

2.2: 19 h / 20 °C

With 4-methyl-morpholine; ethylmagnesium bromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In diethyl ether; dichloromethane;
DOI:10.1021/ml100196d