N-METHOXYMETHYL-1-TRIFLUOROMETHYL-CYCLOPROPANECARBOXYLIC ACID AMIDE

Base Information

• Chemical Name: N-METHOXYMETHYL-1-TRIFLUOROMETHYL-CYCLOPROPANECARBOXYLIC ACID AMIDE
• CAS No.: 1011460-56-2
• Molecular Formula: C₇H₁₀F₃NO₂
• Molecular Weight: 197.157
• Mol file: 1011460-56-2.mol

Synonyms:1-trifluoromethyl-cyclopropanecarboxylic acid methoxy-methyl amide

Chemical Property of N-METHOXYMETHYL-1-TRIFLUOROMETHYL-CYCLOPROPANECARBOXYLIC ACID AMIDE

Chemical Property:

• Boiling Point: 155.3±43.0 °C(Predicted)
• Density: 1.349±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

N-Methoxy-N-methyl-1-(trifluoromethyl)cyclopropanecarboxamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-METHOXYMETHYL-1-TRIFLUOROMETHYL-CYCLOPROPANECARBOXYLIC ACID AMIDE

There total 2 articles about N-METHOXYMETHYL-1-TRIFLUOROMETHYL-CYCLOPROPANECARBOXYLIC ACID AMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 1-(trifluoromethyl)cyclopropanecarboxylic acid (277756-46-4) → 1-trifluoromethyl-cyclopropanecarboxylic acid methoxy-methyl amide (1011460-56-2)

Guidance literature:

1-(trifluoromethyl)cyclopropanecarboxylic acid; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h;

DOI:10.1039/c2ob27113c

Reference yield: 90.0%

1-(trifluoromethyl)cyclopropanecarboxylic acid (277756-46-4) + N,0-dimethylhydroxylamine (1117-97-1) → 1-trifluoromethyl-cyclopropanecarboxylic acid methoxy-methyl amide (1011460-56-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1021/jm5013598

Reference yield: 92.0%

1-trifluoromethyl-cyclopropanecarboxylic acid methoxy-methyl amide (1011460-56-2) + N-trityl-4(5)-iodoimidazole (96797-15-8) → (2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone (1022154-58-0)

Guidance literature:

N-trityl-4⁽⁵⁾-iodoimidazole; With ethylmagnesium bromide; In dichloromethane; at 5 - 25 ℃; Large scale reaction;

1-trifluoromethyl-cyclopropanecarboxylic acid methoxy-methyl amide; In dichloromethane; at 20 ℃; for 15h; Large scale reaction;

DOI:10.1021/op9000274

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

1-(trifluoromethyl)cyclopropanecarboxylic acid

N,0-dimethylhydroxylamine

Downstream raw materials:

(4-chloro-2-methylphenyl)(1-(trifluoromethyl)cyclopropyl)methanone

(2-methyl-1-trityl-1H-imidazol-4-yl)-(1-trifluoromethyl-cyclopropyl)-methanone

2-methyl-4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1-trityl-1H-imidazole

2-[4-(1H-pyrazol-1-yl)phenyl]-1-(4-{[1-(trifluoromethyl)cyclopropyl]methyl}-1H-imidazol-2-yl)propan-2-ol

Refernces

• 1、 -. "KCNQ Potentiators". Paragraph 0037-0038. . Retrieved 2020/08/20.
• 2、 -. "Substituted Pyrrolidines and Methods of Use". Paragraph 2154. . Retrieved 2018/04/20.