3-[(4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

Base Information

• Chemical Name: 3-[(4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester
• CAS No.: 1455094-71-9
• Molecular Formula: C₂₃H₂₄N₂O₆
• Molecular Weight: 424.453
• Mol file: 1455094-71-9.mol

Synonyms:3-[(4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

Chemical Property of 3-[(4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[(4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

There total 9 articles about 3-[(4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[(4-hydroxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester (1455094-69-5) → 3-[(4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester (1455094-71-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

2-(chloromethyl)-4-phenoxybenzoic acid methyl ester (1455091-04-9) → 3-[(4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester (1455094-71-9)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 50 °C

2: sodium methylate / dimethyl sulfoxide; methanol / 0.5 h / 20 °C

3: ethanol / 18 h / Reflux

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

With sodium methylate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

2-cyano-2-methyl-propionic acid ethyl ester (1572-98-1) → 3-[(4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester (1455094-71-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / ethanol / 20 h / 20 °C

2: ethanol / 18 h / Reflux

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 20 °C

With hydrogen; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;

upstream raw materials:

2-(chloromethyl)-4-phenoxybenzoic acid methyl ester

2-cyano-2-methyl-propionic acid ethyl ester

3-amino-2,2-dimethylpropionic acid ethyl ester

2-{[(methoxycarbonylmethyl)(toluene-4-sulfonyl)amino]methyl}-4-phenoxybenzoic acid methyl ester

Downstream raw materials:

3-[(4-hydroxy-1-iodo-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid ethyl ester

3-[(1-cyano-4-hydroxy-2-oxy-7-phenoxyisoquinoline-3-carbonyl)amino]-2,2-dimethylpropionic acid

Refernces