3-fluoro-5-methoxypicolinic acid

Base Information

• Chemical Name: 3-fluoro-5-methoxypicolinic acid
• CAS No.: 1227511-52-5
• Molecular Formula: C₇H₆FNO₃
• Molecular Weight: 171.128
• Mol file: 1227511-52-5.mol

Synonyms:3-fluoro-5-methoxypyridine-2-carboxylic acid

Chemical Property of 3-fluoro-5-methoxypicolinic acid

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

3-Fluoro-5-methoxypicolinicAcid ^*data from reagent suppliers

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Technology Process of 3-fluoro-5-methoxypicolinic acid

There total 5 articles about 3-fluoro-5-methoxypicolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3-fluoro-5-methoxypicolinic acid methyl ester (1256787-03-7) → 3-fluoro-5-methoxypyridine-2-carboxylic acid (1227511-52-5)

Guidance literature:

3-fluoro-5-methoxypicolinic acid methyl ester; With water; lithium hydroxide; In tetrahydrofuran; at 25 ℃; for 0.5h;

With citric acid; In tetrahydrofuran; water; pH=5;

Reference yield:

3,5-difluoropyridine-2-carboxylic acid (745784-04-7) + methyl iodide (74-88-4) → 3-fluoro-5-methoxypyridine-2-carboxylic acid (1227511-52-5) + 5-fluoro-3-methoxypyridine-2-carboxylic acid

Guidance literature:

3,5-difluoropyridine-2-carboxylic acid; With lithium hydroxide monohydrate; In water; at 100 ℃; for 20h; Sealed tube;

methyl iodide; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 64h;

With lithium hydroxide monohydrate; In methanol; water; at 0 - 20 ℃; for 1h; Overall yield = 1.67 g;

Reference yield:

3,5-difluoropyridine-2-carbonitrile (298709-29-2) + sodium methylate (124-41-4) → 3-fluoro-5-methoxypyridine-2-carboxylic acid (1227511-52-5) + 5-fluoro-3-methoxypyridine-2-carboxylic acid

Guidance literature:

3,5-difluoropyridine-2-carbonitrile; sodium methylate; In methanol; at 0 - 20 ℃; for 6h;

With sulfuric acid; water; at 110 ℃; for 16h;

DOI:10.1021/acs.jmedchem.9b00218

upstream raw materials:

3,5-difluoropyridine-2-carboxylic acid

C₁₀H₁₁F₂NO₂

3-fluoro-5-methoxypicolinic acid methyl ester

methyl iodide

Downstream raw materials:

N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-3-fluoro-5-methoxypicolinamide

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