(S)-3-(4-methoxyphenyl)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

Base Information

Chemical Name:(S)-3-(4-methoxyphenyl)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide
CAS No.:1365284-32-7
Molecular Formula:C₂₁H₁₉NO₃S
Molecular Weight:365.453
Hs Code.:

Synonyms:(S)-3-(4-methoxyphenyl)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(4-methoxyphenyl)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

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Technology Process of (S)-3-(4-methoxyphenyl)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

There total 3 articles about (S)-3-(4-methoxyphenyl)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 38938-54-4
3-(4-methylphenyl)-1,2-benzoisothiazole 1,1-dioxide

: 7294-51-1
2,4,6-tris(4-methoxyphenyl)boroxine

: 1365284-32-7
(S)-3-(4-methoxyphenyl)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

Guidance literature:: With di-μ-chloro-bis[(η⁵-(4`R,5`R)-(Sp)-2-(2`-4`,5`-dihydro-4`,5`-diphenyl-1`-tosyl-1`H-imidazolyl)cyclopentadienyl,1-C,3`-N)(η⁵-cyclopentadienyl)-iron(II)]dipalladium(II); potassium acetate; silver(I) acetate; In chlorobenzene; at 50 ℃; for 20h; enantioselective reaction; Inert atmosphere;
DOI:10.1002/chem.201605244

Reference yield: 92.0%

: 38938-55-5
3-(4-methoxyphenyl)-1,2-benzisothiazole 1,1-dioxide

: 5084-80-0
tri(4-tolyl)boroxine

: 1365284-32-7
(S)-3-(4-methoxyphenyl)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

Guidance literature:: With potassium phosphate; tert-Amyl alcohol; 2C₂₅H₃₄O₂*2ClRh; In 1,4-dioxane; at 60 ℃; for 12h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja300697c

Reference yield:

: 4294-57-9
para-methylphenylmagnesium bromide

: 81-07-2
saccharin

: 1365284-32-7
(S)-3-(4-methoxyphenyl)-3-(p-tolyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2: di-μ-chloro-bis[(η⁵-(4`R,5`R)-(Sp)-2-(2`-4`,5`-dihydro-4`,5`-diphenyl-1`-tosyl-1`H-imidazolyl)cyclopentadienyl,1-C,3`-N)(η⁵-cyclopentadienyl)-iron(II)]dipalladium(II); silver(I) acetate; potassium acetate / chlorobenzene / 20 h / 50 °C / Inert atmosphere

With di-μ-chloro-bis[(η⁵-(4`R,5`R)-(Sp)-2-(2`-4`,5`-dihydro-4`,5`-diphenyl-1`-tosyl-1`H-imidazolyl)cyclopentadienyl,1-C,3`-N)(η⁵-cyclopentadienyl)-iron(II)]dipalladium(II); potassium acetate; silver(I) acetate; In tetrahydrofuran; chlorobenzene;
DOI:10.1002/chem.201605244