(R)-5-(Biphenyl-4-yloxymethoxy)-3-hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-5-phenethyl-octanoic acid methyl ester

Base Information

Chemical Name:(R)-5-(Biphenyl-4-yloxymethoxy)-3-hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-5-phenethyl-octanoic acid methyl ester
CAS No.:215317-17-2
Molecular Formula:C₃₉H₄₅NO₇
Molecular Weight:639.789
Hs Code.:

Synonyms:(R)-5-(Biphenyl-4-yloxymethoxy)-3-hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-5-phenethyl-octanoic acid methyl ester

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Chemical Property of (R)-5-(Biphenyl-4-yloxymethoxy)-3-hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-5-phenethyl-octanoic acid methyl ester

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Technology Process of (R)-5-(Biphenyl-4-yloxymethoxy)-3-hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-5-phenethyl-octanoic acid methyl ester

There total 4 articles about (R)-5-(Biphenyl-4-yloxymethoxy)-3-hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-5-phenethyl-octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.7%

: 215317-14-9
(R)-3-(2-phenylethyl)-3-[(4-phenylphenoxy)methoxy]hexanal

: 215316-63-5
(S)-3-(3-Nitrophenyl)pentanoic acid methyl ester

: 215317-17-2
(R)-5-(Biphenyl-4-yloxymethoxy)-3-hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-5-phenethyl-octanoic acid methyl ester

Guidance literature:: With sodium hexamethyldisilazane; In tetrahydrofuran; at -90 - -71 ℃;
DOI:10.1021/jo9809229

Reference yield:

: 215317-11-6
(R)-3-(2-phenylethyl)-3-[(4-phenylphenoxy)methoxy]hexanol

: 215317-17-2
(R)-5-(Biphenyl-4-yloxymethoxy)-3-hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-5-phenethyl-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98.6 percent / KBr, NaHCO₃, 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy, NaOCl / H₂O / 1 h / 1 - 5 °C

2: 89.7 percent / NaHMDS / tetrahydrofuran / -90 - -71 °C

With sodium hypochlorite; TEMPOL; sodium hexamethyldisilazane; sodium hydrogencarbonate; potassium bromide; In tetrahydrofuran; water;
DOI:10.1021/jo9809229

Reference yield:

: 215317-08-1
(R)-(4-phenylphenoxy)methyl-3-(2-phenylethyl)-3-[(4-phenylphenoxy)methoxy]hexanoate

: 215317-17-2
(R)-5-(Biphenyl-4-yloxymethoxy)-3-hydroxy-2-[(S)-1-(3-nitro-phenyl)-propyl]-5-phenethyl-octanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 77.8 percent / DIBALH / toluene / -20 - 1 °C

2: 98.6 percent / KBr, NaHCO₃, 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy, NaOCl / H₂O / 1 h / 1 - 5 °C

3: 89.7 percent / NaHMDS / tetrahydrofuran / -90 - -71 °C

With sodium hypochlorite; TEMPOL; sodium hexamethyldisilazane; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium bromide; In tetrahydrofuran; water; toluene;
DOI:10.1021/jo9809229