1-(2-methoxyphenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate

Base Information

• Chemical Name: 1-(2-methoxyphenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate
• CAS No.: 1416982-13-2
• Molecular Formula: CF₃O₃S*C₁₁H₁₈NO
• Molecular Weight: 329.34
• Mol file: 1416982-13-2.mol

Synonyms:1-(2-methoxyphenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate

Chemical Property of 1-(2-methoxyphenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-methoxyphenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate

There total 3 articles about 1-(2-methoxyphenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

[(2-methoxyphenyl)methyl]dimethylamine (58774-83-7) + methyl trifluoromethanesulfonate (333-27-7) → 1-(2-methoxyphenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate (1416982-13-2)

Guidance literature:

In diethyl ether; at 0 ℃; for 0.25h;

DOI:10.1021/ja3089422

Reference yield:

2-methoxybenzylamine (6850-57-3) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + methyl trifluoromethanesulfonate (333-27-7) → 1-(2-methoxyphenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate (1416982-13-2)

Guidance literature:

2-methoxybenzylamine; formaldehyd; With formic acid; at 100 ℃; for 24h;

methyl trifluoromethanesulfonate; In diethyl ether; Cooling with ice;

DOI:10.1021/acs.oprd.9b00194

Reference yield:

2-methoxybenzylamine (6850-57-3) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + dimethyl amine (124-40-3) + methyl trifluoromethanesulfonate (333-27-7) → 1-(2-methoxyphenyl)-N,N,N-trimethylmethanaminium trifluoromethanesulfonate (1416982-13-2)

Guidance literature:

2-methoxybenzylamine; formaldehyd; With formic acid; sodium cyanoborohydride; In methanol; at 0 - 20 ℃; for 16h; pH=3 - 4; Inert atmosphere;

dimethyl amine; methyl trifluoromethanesulfonate; In methanol; diethyl ether; at 0 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.5b02557

upstream raw materials:

[(2-methoxyphenyl)methyl]dimethylamine

methyl trifluoromethanesulfonate

2-methoxybenzylamine

formaldehyd

Downstream raw materials:

2,4'-dimethoxydiphenylmethane

2-(2-methoxybenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1-(2-methoxy-benzyl)-1H-indole

C₁₆H₁₈O₂Se₂

Refernces

• 1、 Li, Fuhai,Wang, Dan,Chen, Hongyi,He, Ze,Zhou, Lihong,Zeng, Qingle. "Transition metal-free coupling reactions of benzylic trimethylammonium salts with di(hetero)aryl disulfides and diselenides". supporting information. p. 13029 - 13032. Retrieved 2020/11/07.
• 2、 Chen, Hongyi,Yang, Hongqin,Li, Nutao,Xue, Xinghua,He, Ze,Zeng, Qingle. "Palladium-Catalyzed C-N Cross-Coupling of NH-Heteroarenes and Quaternary Ammonium Salts via C-N Bond Cleavage". . p. 1679 - 1685. Retrieved 2019/08/20.