tert-Butyl (6R)-6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Base Information

Chemical Name:tert-Butyl (6R)-6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate
CAS No.:1092938-13-0
Molecular Formula:C₃₀H₃₅N₃O₄
Molecular Weight:501.626
Hs Code.:

Synonyms:tert-Butyl (6R)-6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

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Chemical Property of tert-Butyl (6R)-6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

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Technology Process of tert-Butyl (6R)-6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

There total 11 articles about tert-Butyl (6R)-6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1092938-82-3
tert-butyl (6R)-6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

: 1092938-83-4
5-ethyl-2-tributylstannyl pyridine

: 1092938-13-0
tert-Butyl (6R)-6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 12h; Inert atmosphere; Reflux;

Reference yield:

: 19842-08-1
2-bromo-5-ethylpyridine

: 1092938-13-0
tert-Butyl (6R)-6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1: n-butyllithium / hexane; tetrahydrofuran / 14.5 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 12 h / Inert atmosphere; Reflux

With n-butyllithium; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; toluene;

Reference yield:

: 62327-21-3
tert-butyl dimethylphosphonoacetate

: 1092938-13-0
tert-Butyl (6R)-6-{[5-(5-ethylpyridin-2-yl)-6-phenylfuro[2,3-d]pyrimidin-4-yl]oxy}heptanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Cooling

1.2: -78 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

3.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 12 h / Inert atmosphere; Reflux

With hydrogen; sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;