Technology Process of ethyl 3-{[5-(biphenyl-4-yl)-1-(biphenyl-4-ylmethyl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate
There total 10 articles about ethyl 3-{[5-(biphenyl-4-yl)-1-(biphenyl-4-ylmethyl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: potassium carbonate / tetrahydrofuran / 15 h / 20 °C
2: acetic acid; N-iodo-succinimide / 2 h / 70 °C
3: acetic acid; iron / ethanol; water / 2 h / 76 °C
4: dimethyl sulfoxide / 16 h / 20 °C
5: caesium carbonate / tert-butyl methyl ether; tetrahydrofuran / 20 °C
6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 17 h / 20 °C
7: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 80 °C
8: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 0.75 h / 120 °C
With
N-iodo-succinimide; iron; potassium carbonate; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; 3-chloro-benzenecarboperoxoic acid;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; ethanol; dichloromethane; tert-butyl methyl ether; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 80 °C
2: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 0.75 h / 120 °C
With
potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
tetrakis(triphenylphosphine) palladium(0);
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium tetrahydroborate / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 1 h / 80 °C
3: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / N,N-dimethyl-formamide / 0.75 h / 120 °C
With
sodium tetrahydroborate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; N,N-dimethyl-formamide;
