(+/-)-1-(3-bromophenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-propanol

Base Information

• Chemical Name: (+/-)-1-(3-bromophenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-propanol
• CAS No.: 762272-99-1
• Molecular Formula: C₁₈H₂₁BrO₂
• Molecular Weight: 349.268
• Mol file: 762272-99-1.mol

Synonyms:(+/-)-1-(3-bromophenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-propanol

Chemical Property of (+/-)-1-(3-bromophenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-1-(3-bromophenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-propanol

There total 4 articles about (+/-)-1-(3-bromophenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methylmagnesium bromide (75-16-1) + 2-[3-(3-bromophenyl)-3-hydroxypropyl]benzoic acid methyl ester (762272-95-7) → (+/-)-1-(3-bromophenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-propanol (762272-99-1)

Guidance literature:

In tetrahydrofuran; diethyl ether; at 23 ℃; for 3.5h;

DOI:10.1002/adsc.200303188

Reference yield: 81.0%

methylmagnesium chloride (676-58-4) + 2-[3-(3-bromophenyl)-3-hydroxypropyl]benzoic acid methyl ester (762272-95-7) → (+/-)-1-(3-bromophenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-propanol (762272-99-1)

Guidance literature:

methylmagnesium chloride; With zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 1h;

2-[3-(3-bromophenyl)-3-hydroxypropyl]benzoic acid methyl ester; In tetrahydrofuran; at 0 ℃; for 5.5h;

Reference yield:

1-(3-bromophenyl)-3-[2-(1-hydroxy-1-methylethyl)phenyl]propan-1-one (762272-97-9) → (+/-)-1-(3-bromophenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-propanol (762272-99-1)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at 0 - 23 ℃;

DOI:10.1002/adsc.200303188

upstream raw materials:

methylmagnesium bromide

2-[3-(3-bromophenyl)-3-hydroxypropyl]benzoic acid methyl ester

1-(3-bromophenyl)-3-[2-(1-hydroxy-1-methylethyl)phenyl]propan-1-one

2-[3-(3-bromo-phenyl)-3-oxo-propyl]-benzoic acid methyl ester

Downstream raw materials:

1-(3-bromophenyl)-3-[2-(1-hydroxy-1-methylethyl)phenyl]propan-1-one

(S,E)-1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propan-1-ol

(S)-1-(3-bromo-phenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-1-ol