(S)-1-(3-bromo-phenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-1-ol

Base Information

Chemical Name:(S)-1-(3-bromo-phenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-1-ol
CAS No.:762273-01-8
Molecular Formula:C₁₈H₂₁BrO₂
Molecular Weight:349.268
Hs Code.:

Synonyms:(S)-1-(3-bromo-phenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-1-ol

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Chemical Property of (S)-1-(3-bromo-phenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-1-ol

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Technology Process of (S)-1-(3-bromo-phenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-1-ol

There total 8 articles about (S)-1-(3-bromo-phenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 75-16-1
methylmagnesium bromide

: (S)-2-[3-(3-bromo-phenyl)-3-hydroxy-propyl]-benzoic acid methyl ester

: 762273-01-8
(S)-1-(3-bromo-phenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-1-ol

Guidance literature:: methylmagnesium bromide; (S)-2-[3-(3-bromo-phenyl)-3-hydroxy-propyl]-benzoic acid methyl ester; In tetrahydrofuran; diethyl ether; toluene; at 10 - 20 ℃; for 3.5h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; toluene;

Reference yield: 72.0%

: 676-58-4
methylmagnesium chloride

: (S)-2-[3-(3-bromo-phenyl)-3-hydroxy-propyl]-benzoic acid methyl ester

: 762273-01-8
(S)-1-(3-bromo-phenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-1-ol

Guidance literature:: In tetrahydrofuran; toluene; at 0 - 5 ℃; for 4h;
DOI:10.1080/00397911.2012.684755

Reference yield:

: 762272-99-1
(+/-)-1-(3-bromophenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)-1-propanol

: 762272-97-9
1-(3-bromophenyl)-3-[2-(1-hydroxy-1-methylethyl)phenyl]propan-1-one

: 762273-01-8
(S)-1-(3-bromo-phenyl)-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propan-1-ol

Guidance literature:: With oxygen; caesium carbonate; (-)-sparteine; dichloro(norbornadiene)palladium(II); In toluene; tert-butyl alcohol; at 80 ℃; for 4.5h; under 760.051 Torr;
DOI:10.1002/adsc.200303188