4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl (4-nitrophenyl)carbonate

Base Information

• Chemical Name: 4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl (4-nitrophenyl)carbonate
• CAS No.: 1202249-33-9
• Molecular Formula: C₂₀H₂₅NO₆Si
• Molecular Weight: 403.507
• Mol file: 1202249-33-9.mol

Synonyms:4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl (4-nitrophenyl)carbonate

Chemical Property of 4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl (4-nitrophenyl)carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl (4-nitrophenyl)carbonate

There total 4 articles about 4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl (4-nitrophenyl)carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-Nitrophenyl chloroformate (7693-46-1) + 4-((tert-butyldimethylsilyloxy)methyl)phenol (126070-20-0) → 4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl (4-nitrophenyl)carbonate (1202249-33-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

Reference yield: 83.0%

tert-butyldimethylsilyl chloride (18162-48-6) + carbonic acid 4-hydroxymethylphenyl ester 4-nitrophenyl ester (334999-60-9) → 4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl (4-nitrophenyl)carbonate (1202249-33-9)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

Reference yield:

(4-hydroxyphenyl)methanol (623-05-2) → 4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl (4-nitrophenyl)carbonate (1202249-33-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

2: triethylamine / dichloromethane / 20 °C

With 1H-imidazole; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-Nitrophenyl chloroformate

4-((tert-butyldimethylsilyloxy)methyl)phenol

(4-hydroxyphenyl)methanol

tert-butyldimethylsilyl chloride

Downstream raw materials:

C₂₃H₄₀N₂O₅Si