methyl 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-4-carboxylate

Base Information

Chemical Name:methyl 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-4-carboxylate
CAS No.:1067649-54-0
Molecular Formula:C₂₅H₂₁Cl₂N₃O₂
Molecular Weight:466.367
Hs Code.:

Synonyms:methyl 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-4-carboxylate

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Chemical Property of methyl 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-4-carboxylate

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Technology Process of methyl 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-4-carboxylate

There total 7 articles about methyl 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1065267-61-9
2-tert-butyl-4-chloro-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine

: 1067649-54-0
methyl 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-4-carboxylate

Guidance literature:: With triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; for 70h;

Reference yield:

: 7504-29-2
1-(2-chlorophenyl)-2-(4-chlorophenyl)ethanone

: 1067649-54-0
methyl 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: N,N-dimethyl-formamide / 16 h / 75 °C

2: sodium hydride / methanol; N,N-dimethyl-formamide; mineral oil / 2.5 h / 95 °C

3: trichlorophosphate / 17 h / 100 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.42 h / 130 °C / Sealed microwave tube

5: methanesulfonic acid; water / 113 °C

6: trichlorophosphate / toluene / 1 h / 108 °C

7: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 70 h

With methanesulfonic acid; water; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 611220-89-4
2-chloro-6-(2-chlorophenyl)-5-(4-chlorophenyl)-pyridine-3-carbonitrile

: 1067649-54-0
methyl 2-tert-butyl-7-(2-chlorophenyl)-6-(4-chlorophenyl)pyrido[2,3-d]pyrimidine-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0.42 h / 130 °C / Sealed microwave tube

2: methanesulfonic acid; water / 113 °C

3: trichlorophosphate / toluene / 1 h / 108 °C

4: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 70 h

With methanesulfonic acid; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trichlorophosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; toluene;