N-(2-bromo-2-(4-fluorophenyl)ethyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(2-bromo-2-(4-fluorophenyl)ethyl)-4-methylbenzenesulfonamide
• CAS No.: 1160817-53-7
• Molecular Formula: C₁₅H₁₅BrFNO₂S
• Molecular Weight: 372.258
• Mol file: 1160817-53-7.mol

Synonyms:N-(2-bromo-2-(4-fluorophenyl)ethyl)-4-methylbenzenesulfonamide

Chemical Property of N-(2-bromo-2-(4-fluorophenyl)ethyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-(2-bromo-2-(4-fluorophenyl)ethyl)-4-methylbenzenesulfonamide

There total 4 articles about N-(2-bromo-2-(4-fluorophenyl)ethyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

para-fluorostyrene (405-99-2) + toluene-4-sulfonamide (70-55-3) → N-(2-bromo-2-(4-fluorophenyl)ethyl)-4-methylbenzenesulfonamide (1160817-53-7)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 40 ℃; for 20h; regioselective reaction; Schlenk technique; Inert atmosphere; Darkness;

DOI:10.1002/adsc.201600821

Reference yield:

para-fluorostyrene (405-99-2) → N-(2-bromo-2-(4-fluorophenyl)ethyl)-4-methylbenzenesulfonamide (1160817-53-7) + N-(2-bromo-1-(4-fluorophenyl)ethyl)-4-methylbenzenesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: phenyltrimethylammonium tribromide / acetonitrile / 12 h / 20 °C

2: tris(2,2'-bipyridyl)ruthenium dichloride; sodium persulfate; lithium bromide; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate / 3 h / 20 °C / Irradiation

With sodium persulfate; tris(2,2'-bipyridyl)ruthenium dichloride; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; phenyltrimethylammonium tribromide; lithium bromide; In acetonitrile;

DOI:10.1002/adsc.201400476

Reference yield:

chloroamine-T (127-65-1) → N-(2-bromo-2-(4-fluorophenyl)ethyl)-4-methylbenzenesulfonamide (1160817-53-7) + N-(2-bromo-1-(4-fluorophenyl)ethyl)-4-methylbenzenesulfonamide

Guidance literature:

Multi-step reaction with 2 steps

1: phenyltrimethylammonium tribromide / acetonitrile / 12 h / 20 °C

2: tris(2,2'-bipyridyl)ruthenium dichloride; sodium persulfate; lithium bromide; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate / 3 h / 20 °C / Irradiation

With sodium persulfate; tris(2,2'-bipyridyl)ruthenium dichloride; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; phenyltrimethylammonium tribromide; lithium bromide; In acetonitrile;

DOI:10.1002/adsc.201400476

upstream raw materials:

para-fluorostyrene

toluene-4-sulfonamide

chloroamine-T

2-(4-fluoro-phenyl)-1-(toluene-4-sulfonyl)-aziridine