[[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid dimethyl ester

Base Information

• Chemical Name: [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid dimethyl ester
• CAS No.: 86727-46-0
• Molecular Formula: C₁₈H₃₀NO₉P
• Molecular Weight: 435.411
• Mol file: 86727-46-0.mol

Synonyms:[[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid dimethyl ester

Chemical Property of [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid dimethyl ester

There total 1 articles about [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloroformic acid ethyl ester (541-41-3) + 3,4-dimethoxy-benzaldehyde (120-14-9) + 2,2-dimethoxyethylamine (22483-09-6) + phosphorous acid trimethyl ester (121-45-9) → [[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid dimethyl ester (86727-46-0)

Guidance literature:

Multistep reaction; 1) reflux; 2) -10 deg C, 5 min; 3) room temp., 15 h;

DOI:10.1021/jo00167a043

Reference yield: 57.0%

[[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid dimethyl ester (86727-46-0) → 6,7-dimethoxyisoquinoline (15248-39-2)

Guidance literature:

With titanium tetrachloride; In dichloromethane; for 36h; Heating;

DOI:10.1021/jo00167a043

Reference yield:

[[(2,2-Dimethoxy-ethyl)-ethoxycarbonyl-amino]-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid dimethyl ester (86727-46-0) → Papaverine (58-74-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) n-butyllithium / 1) THF, -78 deg C, 15 min; 2) THF, 0.5 h at -78 deg C, then 3 h at room temp.

2: 64 mg / TiCl₄ / CH₂Cl₂ / 1.) -78 deg C, 15 min, 2.) room temp. 3 h

With n-butyllithium; titanium tetrachloride; In dichloromethane;

DOI:10.1021/jo00167a043

upstream raw materials:

chloroformic acid ethyl ester

3,4-dimethoxy-benzaldehyde

2,2-dimethoxyethylamine

phosphorous acid trimethyl ester

Downstream raw materials:

6,7-dimethoxyisoquinoline

[(Z)-1,2-Bis-(3,4-dimethoxy-phenyl)-vinyl]-(2,2-dimethoxy-ethyl)-carbamic acid ethyl ester

Papaverine

2,3-Bis-(3,4-dimethoxy-phenyl)-pyrrole-1-carboxylic acid ethyl ester